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9.A.14.13.16
The P2Y purinoreceptor 2, P2Y2 of 377 aas and 7 TMSs.  Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.  Plays a role in shedding (Pupovac and Sluyter 2016).  There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14), and they play a variety of roles in cell physiology (von Kügelgen and Hoffmann 2016).  The 3-d x-ray structure of a P2Y2 receptor is known (Jacobson et al. 2015).  Antagonists stabilize an ionic lock within the P2T1 receptor, but binding of ADP breaks this ionic lock, forming a continuous water channel that leads to P2Y1 receptor activation (Yuan et al. 2016).

Accession Number:P41231
Protein Name:P2Y purinoceptor 2
Length:377
Molecular Weight:42273.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL NAVALYIFLC 
61:	RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP FSTVLCKLVR FLFYTNLYCS 
121:	ILFLTCISVH RCLGVLRPLR SLRWGRARYA RRVAGAVWVL VLACQAPVLY FVTTSARGGR 
181:	VTCHDTSAPE LFSRFVAYSS VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK 
241:	RKSVRTIAVV LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC 
301:	LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE DVLGSSEDSR 
361:	RTESTPAGSE NTKDIRL