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9.A.14.13.19
The G-protein-coupled estrogen receptor, GPER (Gpr30; GPER1) of 375 aas and 7 TMSs.  GPER binds to 17-beta-estradiol (E2) with high affinity and aldosterone with lower affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Activating GPR30 by estrogen results in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. Thus, GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology. It stimulates cAMP production, calcium mobilization and tyrosine kinase Src (Gros et al. 2013; Gaudet et al. 2015).

Accession Number:Q99527
Protein Name:G-protein coupled estrogen receptor 1
Length:375
Molecular Weight:42248.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Nucleus1
Substrate NONE

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FASTA formatted sequence
1:	MDVTSQARGV GLEMYPGTAQ PAAPNTTSPE LNLSHPLLGT ALANGTGELS EHQQYVIGLF 
61:	LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN LAVADLILVA DSLIEVFNLH 
121:	ERYYDIAVLC TFMSLFLQVN MYSSVFFLTW MSFDRYIALA RAMRCSLFRT KHHARLSCGL 
181:	IWMASVSATL VPFTAVHLQH TDEACFCFAD VREVQWLEVT LGFIVPFAII GLCYSLIVRV 
241:	LVRAHRHRGL RPRRQKALRM ILAVVLVFFV CWLPENVFIS VHLLQRTQPG AAPCKQSFRH 
301:	AHPLTGHIVN LAAFSNSCLN PLIYSFLGET FRDKLRLYIE QKTNLPALNR FCHAALKAVI 
361:	PDSTEQSDVR FSSAV