TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.A.14.13.25
G-protein coupled receptor 139, GPR139, GPRG1 or PGR3, of 353 aas and 7 TMSs.  It is an orphan receptor that seems to act through a G(q/11)-mediated pathway.  GPR139 and the dopamine D2 receptor co-express in the same cells of the brain and may functionally interact (Wang et al. 2019). Loss of GPR139 enhanced effects of morphine in mice but reduced withdrawal effects (Wang et al. 2019). It is a regulator of opioid receptors (Lindsay and Scherrer 2019).  

Accession Number:Q6DWJ6
Protein Name:Probable G-protein coupled receptor 139
Length:353
Molecular Weight:40679.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MEHTHAHLAA NSSLSWWSPG SACGLGFVPV VYYSLLLCLG LPANILTVII LSQLVARRQK 
61:	SSYNYLLALA AADILVLFFI VFVDFLLEDF ILNMQMPQVP DKIIEVLEFS SIHTSIWITV 
121:	PLTIDRYIAV CHPLKYHTVS YPARTRKVIV SVYITCFLTS IPYYWWPNIW TEDYISTSVH 
181:	HVLIWIHCFT VYLVPCSIFF ILNSIIVYKL RRKSNFRLRG YSTGKTTAIL FTITSIFATL 
241:	WAPRIIMILY HLYGAPIQNR WLVHIMSDIA NMLALLNTAI NFFLYCFISK RFRTMAAATL 
301:	KAFFKCQKQP VQFYTNHNFS ITSSPWISPA NSHCIKMLVY QYDKNGKPIK VSP