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|---|---|
| Accession Number: | P25105 |
| Protein Name: | Platelet-activating factor receptor |
| Length: | 342 |
| Molecular Weight: | 39203.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 7 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | NONE |
Cross database links:
| Genevestigator: | P25105 |
|---|---|
| eggNOG: | NOG149133 |
| HEGENOM: | HBG444635 |
| Entrez Gene ID: | 5724 |
| Pfam: | PF00001 |
| KEGG: | hsa:5724 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005634
C:nucleus
GO:0005543
F:phospholipid binding
GO:0004992
F:platelet activating factor receptor activity
GO:0006935
P:chemotaxis
GO:0006954
P:inflammatory response
GO:0060333
P:interferon-gamma-mediated signaling pathway
GO:0048015
P:phosphatidylinositol-mediated signaling
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References (10)[1] “Characterization of a human cDNA that encodes a functional receptor for platelet activating factor.” Ye R.D.et.al. 1656963 [2] “Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.” Nakamura M.et.al. 1657923 [3] “The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.” Kunz D.et.al. 1374385 [4] “The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1.” Seyfried C.E.et.al. 1322356 [5] “Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.” Sugimoto T.et.al. 1281995 [6] “Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region.” Chase P.B.et.al. 8383507 [7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [9] “Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation.” McLaughlin N.J.et.al. 16709866 [10] “Characterization of single-nucleotide polymorphisms in coding regions of human genes.” Cargill M.et.al. 10391209
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | |||||
| FASTA formatted sequence |
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1: MEPHDSSHMD SEFRYTLFPI VYSIIFVLGV IANGYVLWVF ARLYPCKKFN EIKIFMVNLT 61: MADMLFLITL PLWIVYYQNQ GNWILPKFLC NVAGCLFFIN TYCSVAFLGV ITYNRFQAVT 121: RPIKTAQANT RKRGISLSLV IWVAIVGAAS YFLILDSTNT VPDSAGSGNV TRCFEHYEKG 181: SVPVLIIHIF IVFSFFLVFL IILFCNLVII RTLLMQPVQQ QRNAEVKRRA LWMVCTVLAV 241: FIICFVPHHV VQLPWTLAEL GFQDSKFHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF 301: RKHLTEKFYS MRSSRKCSRA TTDTVTEVVV PFNQIPGNSL KN
