TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.A.14.13.3
Platelet-activating factor receptor

Accession Number:P25105
Protein Name:Platelet-activating factor receptor
Length:342
Molecular Weight:39203.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P25105
eggNOG: NOG149133
HEGENOM: HBG444635
Entrez Gene ID: 5724   
Pfam: PF00001   
KEGG: hsa:5724   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005634 C:nucleus
GO:0005543 F:phospholipid binding
GO:0004992 F:platelet activating factor receptor activity
GO:0006935 P:chemotaxis
GO:0006954 P:inflammatory response
GO:0060333 P:interferon-gamma-mediated signaling pathway
GO:0048015 P:phosphatidylinositol-mediated signaling

References (10)

[1] “Characterization of a human cDNA that encodes a functional receptor for platelet activating factor.”  Ye R.D.et.al.   1656963
[2] “Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.”  Nakamura M.et.al.   1657923
[3] “The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.”  Kunz D.et.al.   1374385
[4] “The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1.”  Seyfried C.E.et.al.   1322356
[5] “Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.”  Sugimoto T.et.al.   1281995
[6] “Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region.”  Chase P.B.et.al.   8383507
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation.”  McLaughlin N.J.et.al.   16709866
[10] “Characterization of single-nucleotide polymorphisms in coding regions of human genes.”  Cargill M.et.al.   10391209

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MEPHDSSHMD SEFRYTLFPI VYSIIFVLGV IANGYVLWVF ARLYPCKKFN EIKIFMVNLT 
61:	MADMLFLITL PLWIVYYQNQ GNWILPKFLC NVAGCLFFIN TYCSVAFLGV ITYNRFQAVT 
121:	RPIKTAQANT RKRGISLSLV IWVAIVGAAS YFLILDSTNT VPDSAGSGNV TRCFEHYEKG 
181:	SVPVLIIHIF IVFSFFLVFL IILFCNLVII RTLLMQPVQQ QRNAEVKRRA LWMVCTVLAV 
241:	FIICFVPHHV VQLPWTLAEL GFQDSKFHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF 
301:	RKHLTEKFYS MRSSRKCSRA TTDTVTEVVV PFNQIPGNSL KN