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9.A.14.13.6
Melanin-concentrating hormone receptor 1

Accession Number:Q99705
Protein Name:Melanin-concentrating hormone receptor 1
Length:422
Molecular Weight:45963.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q99705 Q99705 Q99705
eggNOG: NOG282817 NOG282817 NOG282817
HEGENOM: HOG000000704 HOG000000704 HOG000000704
Entrez Gene ID: 2847   
Pfam: PF00001   
KEGG: hsa:2847    hsa:2847    hsa:2847   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0031513 C:nonmotile primary cilium
GO:0008188 F:neuropeptide receptor activity
GO:0007204 P:elevation of cytosolic calcium ion concentration
GO:0007631 P:feeding behavior
GO:0006091 P:generation of precursor metabolites and energy
GO:0007193 P:inhibition of adenylate cyclase activity by G-protein signaling pathway
GO:0042562 F:hormone binding
GO:0030273 F:melanin-concentrating hormone receptor activity
GO:0007193 P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0051928 P:positive regulation of calcium ion transport

References (33)

[1] “Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.”  Shimomura Y.et.al.   10441476
[2] “Mutation analysis of the MCHR1 gene in human obesity.”  Wermter A.-K.et.al.   15941924
[3] “A genome annotation-driven approach to cloning the human ORFeome.”  Collins J.E.et.al.   15461802
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The DNA sequence of human chromosome 22.”  Dunham I.et.al.   10591208
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Characterization of a human gene related to genes encoding somatostatin receptors.”  Kolakowski L.F. Jr.et.al.   8977118
[8] “Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.”  Chambers J.et.al.   10421367
[9] “Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.”  Francke F.et.al.   16945926
[10] “Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.”  Gibson W.T.et.al.   15166293
[11] “Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.”  Hawes B.E.et.al.   15340116
[12] “Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.”  Shimomura Y.et.al.   10441476
[13] “Mutation analysis of the MCHR1 gene in human obesity.”  Wermter A.-K.et.al.   15941924
[14] “A genome annotation-driven approach to cloning the human ORFeome.”  Collins J.E.et.al.   15461802
[15] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[16] “The DNA sequence of human chromosome 22.”  Dunham I.et.al.   10591208
[17] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[18] “Characterization of a human gene related to genes encoding somatostatin receptors.”  Kolakowski L.F. Jr.et.al.   8977118
[19] “Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.”  Chambers J.et.al.   10421367
[20] “Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.”  Francke F.et.al.   16945926
[21] “Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.”  Gibson W.T.et.al.   15166293
[22] “Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.”  Hawes B.E.et.al.   15340116
[23] “Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.”  Shimomura Y.et.al.   10441476
[24] “Mutation analysis of the MCHR1 gene in human obesity.”  Wermter A.-K.et.al.   15941924
[25] “A genome annotation-driven approach to cloning the human ORFeome.”  Collins J.E.et.al.   15461802
[26] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[27] “The DNA sequence of human chromosome 22.”  Dunham I.et.al.   10591208
[28] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[29] “Characterization of a human gene related to genes encoding somatostatin receptors.”  Kolakowski L.F. Jr.et.al.   8977118
[30] “Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.”  Chambers J.et.al.   10421367
[31] “Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.”  Francke F.et.al.   16945926
[32] “Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.”  Gibson W.T.et.al.   15166293
[33] “Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.”  Hawes B.E.et.al.   15340116

External Searches:

  • Search: DB with
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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSVGAMKKGV GRAVGLGGGS GCQATEEDPL PNCGACAPGQ GGRRWRLPQP AWVEGSSARL 
61:	WEQATGTGWM DLEASLLPTG PNASNTSDGP DNLTSAGSPP RTGSISYINI IMPSVFGTIC 
121:	LLGIIGNSTV IFAVVKKSKL HWCNNVPDIF IINLSVVDLL FLLGMPFMIH QLMGNGVWHF 
181:	GETMCTLITA MDANSQFTST YILTAMAIDR YLATVHPISS TKFRKPSVAT LVICLLWALS 
241:	FISITPVWLY ARLIPFPGGA VGCGIRLPNP DTDLYWFTLY QFFLAFALPF VVITAAYVRI 
301:	LQRMTSSVAP ASQRSIRLRT KRVTRTAIAI CLVFFVCWAP YYVLQLTQLS ISRPTLTFVY 
361:	LYNAAISLGY ANSCLNPFVY IVLCETFRKR LVLSVKPAAQ GQLRAVSNAQ TADEERTESK 
421:	GT