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9.A.14.13.8
G-protein-coupled receptor GPR35.  Agonists include the tryptophan metabolite kynurenic acid, the synthetic ligand zaprinast and two thiazolidinediones.  Agonist activation involves TMSIII and is transduced via Galpha(1)(3) and beta-arrestin-2 (Jenkins et al. 2011).

Accession Number:Q9HC97
Protein Name:G-protein coupled receptor 35
Length:309
Molecular Weight:34072.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNGTYNTCGS SDLTWPPAIK LGFYAYLGVL LVLGLLLNSL ALWVFCCRMQ QWTETRIYMT 
61:	NLAVADLCLL CTLPFVLHSL RDTSDTPLCQ LSQGIYLTNR YMSISLVTAI AVDRYVAVRH 
121:	PLRARGLRSP RQAAAVCAVL WVLVIGSLVA RWLLGIQEGG FCFRSTRHNF NSMAFPLLGF 
181:	YLPLAVVVFC SLKVVTALAQ RPPTDVGQAE ATRKAARMVW ANLLVFVVCF LPLHVGLTVR 
241:	LAVGWNACAL LETIRRALYI TSKLSDANCC LDAICYYYMA KEFQEASALA VAPSAKAHKS 
301:	QDSLCVTLA