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9.A.14.17.5
Taste receptor type 2 member 38 (T2R38; bitter taste receptor of 333 aas and 7 TMSs) (Gaida et al. 2016).  Activated by the bona fide ligand for T2R38, phenylthiourea (PTU), and by N-acetyl-dodecanoyl homoserine (AHL-12), a quorum sensing molecule of Pseudomonas aeruginosa. The latter is the only known natural ligand for T2R38. In response to PTU or AHL-12, key transcription factors are activated including phosphorylation of the MAP kinases p38 and ERK1/2, and upregulation of NFATc1. Increased expression of the multi-drug resistance protein 1 (ABCB1, TC# 3.A.1.201.1) is also observed, a transporter that shuttles a plethora of drugs, such as chemotherapeutics and antibiotics (Gaida et al. 2016).

Accession Number:P59533
Protein Name:Taste receptor type 2 member 38
Length:333
Molecular Weight:37892.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate NONE

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLTLTRIRTV SYEVRSTFLF ISVLEFAVGF LTNAFVFLVN FWDVVKRQAL SNSDCVLLCL 
61:	SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYQAIIMLWM IANQANLWLA ACLSLLYCSK 
121:	LIRFSHTFLI CLASWVSRKI SQMLLGIILC SCICTVLCVW CFFSRPHFTV TTVLFMNNNT 
181:	RLNWQIKDLN LFYSFLFCYL WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRNSRDPSLE 
241:	AHIKALKSLV SFFCFFVISS CAAFISVPLL ILWRDKIGVM VCVGIMAACP SGHAAILISG 
301:	NAKLRRAVMT ILLWAQSSLK VRADHKADSR TLC