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9.A.14.2.2
Cannabinoid receptor 1. The endocannabinoid system is widely present in the retina where it can modulate neurotransmitter release and ion channel activity (Bouchard et al. 2016). Endogenous endocannabinoids such as anandamide and 2-arachidonoyl glycerol (2AG) bind to the receptor and influence many processes including feeding, learning, memory, pain, emotions, sleep and dreams (Murillo-Rodriguez et al. 2017).

Accession Number:P21554
Protein Name:Cannabinoid receptor 1
Length:472
Molecular Weight:52858.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P21554
eggNOG: NOG148018
Entrez Gene ID: 1268   
Pfam: PF00001   
Drugbank: Drugbank Link   
KEGG: hsa:1268   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0004949 F:cannabinoid receptor activity
GO:0007188 P:G-protein signaling, coupled to cAMP nucleotide second messenger

References (10)

[1] “Nucleotide sequence of a human cannabinoid receptor cDNA.”  Gerard C.et.al.   2263478
[2] “Molecular cloning of a human cannabinoid receptor which is also expressed in testis.”  Gerard C.et.al.   1718258
[3] “An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing.”  Shire D.et.al.   7876112
[4] “Identification and characterisation of a novel splice variant of the human CB1 receptor.”  Ryberg E.et.al.   15620723
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a.”  Niehaus J.L.et.al.   17895407
[9] “Palmitoylation of cysteine 415 of helix 8: effect on membrane localisation and signalling of the CB(1) cannabinoid receptor.”  Oddi S.et.al.   21895628
[10] “Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity.”  Ulfers A.L.et.al.   12237474
Structure:
1LVQ   1LVR   2B0Y   2KOE     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE 
61:	KMTAGDNPQL VPADQVNITE FYNKSLSSFK ENEENIQCGE NFMDIECFMV LNPSQQLAIA 
121:	VLSLTLGTFT VLENLLVLCV ILHSRSLRCR PSYHFIGSLA VADLLGSVIF VYSFIDFHVF 
181:	HRKDSRNVFL FKLGGVTASF TASVGSLFLT AIDRYISIHR PLAYKRIVTR PKAVVAFCLM 
241:	WTIAIVIAVL PLLGWNCEKL QSVCSDIFPH IDETYLMFWI GVTSVLLLFI VYAYMYILWK 
301:	AHSHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV VLIICWGPLL 
361:	AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR SKDLRHAFRS MFPSCEGTAQ 
421:	PLDNSMGDSD CLHKHANNAA SVHRAAESCI KSTVKIAKVT MSVSTDTSAE AL