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9.A.14.3.2
The muscarinic acetylcholine receptor (Jo et al., 2010). Endothelial-dependent muscarinic receptor signaling acts largely through TRPV4 sparklet-mediated stimulation of IK (1.A.1.16.2) and SK (1.A.1.16.1) channels to promote vasodilation.

Accession Number:P12657
Protein Name:Muscarinic acetylcholine receptor M1
Length:460
Molecular Weight:51329.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P12657 P12657
eggNOG: roNOG04436 NOG250863
HEGENOM: HBG713567 HBG713567
Entrez Gene ID: 12669   
Pfam: PF00001   
KEGG: mmu:12669    mmu:12669   

Gene Ontology

GO:0030054 C:cell junction
GO:0016021 C:integral to membrane
GO:0045211 C:postsynaptic membrane
GO:0040012 P:regulation of locomotion
GO:0005886 C:plasma membrane
GO:0016907 F:G-protein coupled acetylcholine receptor activity

References (4)

[1] “Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene.”  Shapiro R.A.et.al.   2848036
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene.”  Shapiro R.A.et.al.   2848036
[4] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
Structure:
5cxv     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNTSVPPAVS PNITVLAPGK GPWQVAFIGS TTGLLSLATV TGNLLVLISI KVNTELKTVN 
61:	NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL WLALDYVASN ASVMNLLLIS 
121:	FDRYFSVTRP LSYRAKRTPR RAALMIGLAW LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI 
181:	QFLSQPIITF GTAMAAFYLP VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS 
241:	SERSQPGAEG SPESPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 
301:	VIKMPMVDPE AQAPTKQPPK SSPNTVKRPT KKGRDRGGKG QKPRGKEQLA KRKTFSLVKE 
361:	KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW ELGYWLCYVN STVNPMCYAS 
421:	CNKAFRDHFR LLLLCRWDKR RWRKIPKRPG SVHRTPSRQC