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9.A.14.4.6
Glucagon-like peptide 1 receptor

Accession Number:P43220
Protein Name:Glucagon-like peptide 1 receptor
Length:463
Molecular Weight:53026.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P43220
eggNOG: NOG263329
HEGENOM: HBG447108
DIP: DIP-29980N
Entrez Gene ID: 2740   
Pfam: PF00002    PF02793   
KEGG: hsa:2740   

Gene Ontology

GO:0004967 F:glucagon receptor activity
GO:0006112 P:energy reserve metabolic process
GO:0044281 P:small molecule metabolic process

References (11)

[1] “Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor.”  Thorens B.et.al.   8405712
[2] “Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor.”  Dillon J.S.et.al.   8404634
[3] “Cloning and functional expression of a human glucagon-like peptide-1 receptor.”  Graziano M.P.et.al.   8216285
[4] “Signal transduction of the GLP-1-receptor cloned from a human insulinoma.”  van Eyll B.et.al.   7517895
[5] “Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences.”  Wei Y.et.al.   7843404
[6] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene.”  Lankat-Buttgereit B.et.al.   9213353
[9] “Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket.”  Mann R.J.et.al.   20869417
[10] “Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase.”  Dezelak M.et.al.   21901419
[11] “Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.”  Runge S.et.al.   18287102
Structure:
3C59   3C5T   3IOL   4ZGM   5E94   5NX2   5OTT   5OTU   5OTV   5OTW   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGAPGPLRL ALLLLGMVGR AGPRPQGATV SLWETVQKWR EYRRQCQRSL TEDPPPATDL 
61:	FCNRTFDEYA CWPDGEPGSF VNVSCPWYLP WASSVPQGHV YRFCTAEGLW LQKDNSSLPW 
121:	RDLSECEESK RGERSSPEEQ LLFLYIIYTV GYALSFSALV IASAILLGFR HLHCTRNYIH 
181:	LNLFASFILR ALSVFIKDAA LKWMYSTAAQ QHQWDGLLSY QDSLSCRLVF LLMQYCVAAN 
241:	YYWLLVEGVY LYTLLAFSVL SEQWIFRLYV SIGWGVPLLF VVPWGIVKYL YEDEGCWTRN 
301:	SNMNYWLIIR LPILFAIGVN FLIFVRVICI VVSKLKANLM CKTDIKCRLA KSTLTLIPLL 
361:	GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI LYCFVNNEVQ LEFRKSWERW 
421:	RLEHLHIQRD SSMKPLKCPT SSLSSGATAG SSMYTATCQA SCS