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9.A.14.4.7
Growth hormone-releasing hormone receptor

Accession Number:Q02643
Protein Name:Growth hormone-releasing hormone receptor
Length:423
Molecular Weight:47402.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q02643
eggNOG: NOG249002
HEGENOM: HBG447108
Entrez Gene ID: 2692   
Pfam: PF00002    PF02793   
Drugbank: Drugbank Link   
KEGG: hsa:2692   

Gene Ontology

GO:0009986 C:cell surface
GO:0016021 C:integral to membrane
GO:0005637 C:nuclear inner membrane
GO:0016363 C:nuclear matrix
GO:0005640 C:nuclear outer membrane
GO:0005886 C:plasma membrane
GO:0030141 C:secretory granule
GO:0019838 F:growth factor binding
GO:0016520 F:growth hormone-releasing hormone receptor activity
GO:0017046 F:peptide hormone binding
GO:0007189 P:activation of adenylate cyclase activity by G-protein signaling pathway
GO:0008284 P:positive regulation of cell proliferation
GO:0060124 P:positive regulation of growth hormone secretion
GO:0043568 P:positive regulation of insulin-like growth factor receptor signaling pathway
GO:0040018 P:positive regulation of multicellular organism growth
GO:0043627 P:response to estrogen stimulus
GO:0051384 P:response to glucocorticoid stimulus

References (7)

[1] “Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.”  Mayo K.E.et.al.   1333056
[2] “Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.”  Gaylinn B.D.et.al.   7680413
[3] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[4] “Three new mutations in the gene for the growth hormone (GH)-releasing hormone receptor in familial isolated GH deficiency type IB.”  Salvatori R.et.al.   11232012
[5] “Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene.”  Salvatori R.et.al.   10084571
[6] “A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency.”  Carakushansky M.et.al.   12534354
[7] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
Structure:
2XDG     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDRRMWGAHV FCVLSPLPTV LGHMHPECDF ITQLREDESA CLQAAEEMPN TTLGCPATWD 
61:	GLLCWPTAGS GEWVTLPCPD FFSHFSSESG AVKRDCTITG WSEPFPPYPV ACPVPLELLA 
121:	EEESYFSTVK IIYTVGHSIS IVALFVAITI LVALRRLHCP RNYVHTQLFT TFILKAGAVF 
181:	LKDAALFHSD DTDHCSFSTV LCKVSVAASH FATMTNFSWL LAEAVYLNCL LASTSPSSRR 
241:	AFWWLVLAGW GLPVLFTGTW VSCKLAFEDI ACWDLDDTSP YWWIIKGPIV LSVGVNFGLF 
301:	LNIIRILVRK LEPAQGSLHT QSQYWRLSKS TLFLIPLFGI HYIIFNFLPD NAGLGIRLPL 
361:	ELGLGSFQGF IVAILYCFLN QEVRTEISRK WHGHDPELLP AWRTRAKWTT PSRSAAKVLT 
421:	SMC