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9.A.14.4.9
Vasoactive intestinal polypeptide receptor 1

Accession Number:P32241
Protein Name:Vasoactive intestinal polypeptide receptor 1
Length:457
Molecular Weight:51547.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P32241
eggNOG: NOG293423
HEGENOM: HBG447108
Entrez Gene ID: 7433   
Pfam: PF00002    PF02793   
KEGG: hsa:7433   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0005887 C:integral to plasma membrane
GO:0005634 C:nucleus
GO:0004999 F:vasoactive intestinal polypeptide receptor activity
GO:0007586 P:digestion
GO:0007187 P:G-protein signaling, coupled to cyclic nucleotide second messenger
GO:0006955 P:immune response
GO:0006936 P:muscle contraction
GO:0008284 P:positive regulation of cell proliferation
GO:0007268 P:synaptic transmission

References (10)

[1] “Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor.”  Sreedharan S.P.et.al.   8390245
[2] “Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains.”  Couvineau A.et.al.   8179610
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Molecular cloning and functional characterization of a human liver vasoactive intestinal peptide receptor.”  Gagnon A.W.et.al.   7917790
[6] “Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP.”  Couvineau A.et.al.   7818527
[7] “Predominant expression of type II vasoactive intestinal peptide receptors by human T lymphoblastoma cells: transduction of both Ca2+ and cyclic AMP signals.”  Xia M.et.al.   8926282
[8] “Importance of conserved cysteines in the extracellular loops of human PACAP/VIP1 receptor for ligand binding and stimulation of cAMP production.”  Knudsen S.M.et.al.   9928020
[9] “Dual, HLA-B27 subtype-dependent conformation of a self-peptide.”  Hulsmeyer M.et.al.   14734527
[10] “Citrullination-dependent differential presentation of a self-peptide by HLA-B27 subtypes.”  Beltrami A.et.al.   18650441
Structure:
1OF2   1OGT   3B3I   3B6S   3DTX   3HCV   5DEF   5DEG   5IB1   5IB2   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRPPSPLPAR WLCVLAGALA WALGPAGGQA ARLQEECDYV QMIEVQHKQC LEEAQLENET 
61:	IGCSKMWDNL TCWPATPRGQ VVVLACPLIF KLFSSIQGRN VSRSCTDEGW THLEPGPYPI 
121:	ACGLDDKAAS LDEQQTMFYG SVKTGYTIGY GLSLATLLVA TAILSLFRKL HCTRNYIHMH 
181:	LFISFILRAA AVFIKDLALF DSGESDQCSE GSVGCKAAMV FFQYCVMANF FWLLVEGLYL 
241:	YTLLAVSFFS ERKYFWGYIL IGWGVPSTFT MVWTIARIHF EDYGCWDTIN SSLWWIIKGP 
301:	ILTSILVNFI LFICIIRILL QKLRPPDIRK SDSSPYSRLA RSTLLLIPLF GVHYIMFAFF 
361:	PDNFKPEVKM VFELVVGSFQ GFVVAILYCF LNGEVQAELR RKWRRWHLQG VLGWNPKYRH 
421:	PSGGSNGATC STQVSMLTRV SPGARRSSSF QAEVSLV