TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.A.14.7.3
G-protein coupled receptor family C group 6 member A

Accession Number:Q5T6X5
Protein Name:G-protein coupled receptor family C group 6 member A
Length:926
Molecular Weight:104753.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q5T6X5 Q5T6X5
eggNOG: NOG295353 NOG295353
HEGENOM: HBG444492 HBG444492
Entrez Gene ID: 222545   
Pfam: PF00003    PF01094    PF07562   
KEGG: hsa:222545    hsa:222545   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0004930 F:G-protein coupled receptor activity
GO:0043200 P:response to amino acid stimulus

References (10)

[1] “Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor.”  Wellendorph P.et.al.   15194188
[2] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[3] “Identification of G protein-coupled receptor genes from the human genome sequence.”  Takeda S.et.al.   12044878
[4] “Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids.”  Wellendorph P.et.al.   15576628
[5] “GPRC6A mediates the non-genomic effects of steroids.”  Pi M.et.al.   20947496
[6] “Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor.”  Wellendorph P.et.al.   15194188
[7] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[8] “Identification of G protein-coupled receptor genes from the human genome sequence.”  Takeda S.et.al.   12044878
[9] “Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids.”  Wellendorph P.et.al.   15576628
[10] “GPRC6A mediates the non-genomic effects of steroids.”  Pi M.et.al.   20947496

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MAFLIILITC FVIILATSQP CQTPDDFVAA TSPGHIIIGG LFAIHEKMLS SEDSPRRPQI 
61:	QECVGFEISV FLQTLAMIHS IEMINNSTLL PGVKLGYEIY DTCTEVTVAM AATLRFLSKF 
121:	NCSRETVEFK CDYSSYMPRV KAVIGSGYSE ITMAVSRMLN LQLMPQVGYE STAEILSDKI 
181:	RFPSFLRTVP SDFHQIKAMA HLIQKSGWNW IGIITTDDDY GRLALNTFII QAEANNVCIA 
241:	FKEVLPAFLS DNTIEVRINR TLKKIILEAQ VNVIVVFLRQ FHVFDLFNKA IEMNINKMWI 
301:	ASDNWSTATK ITTIPNVKKI GKVVGFAFRR GNISSFHSFL QNLHLLPSDS HKLLHEYAMH 
361:	LSACAYVKDT DLSQCIFNHS QRTLAYKANK AIERNFVMRN DFLWDYAEPG LIHSIQLAVF 
421:	ALGYAIRDLC QARDCQNPNA FQPWELLGVL KNVTFTDGWN SFHFDAHGDL NTGYDVVLWK 
481:	EINGHMTVTK MAEYDLQNDV FIIPDQETKN EFRNLKQIQS KCSKECSPGQ MKKTTRSQHI 
541:	CCYECQNCPE NHYTNQTDMP HCLLCNNKTH WAPVRSTMCF EKEVEYLNWN DSLAILLLIL 
601:	SLLGIIFVLV VGIIFTRNLN TPVVKSSGGL RVCYVILLCH FLNFASTSFF IGEPQDFTCK 
661:	TRQTMFGVSF TLCISCILTK SLKILLAFSF DPKLQKFLKC LYRPILIIFT CTGIQVVICT 
721:	LWLIFAAPTV EVNVSLPRVI ILECEEGSIL AFGTMLGYIA ILAFICFIFA FKGKYENYNE 
781:	AKFITFGMLI YFIAWITFIP IYATTFGKYV PAVEIIVILI SNYGILYCTF IPKCYVIICK 
841:	QEINTKSAFL KMIYSYSSHS VSSIALSPAS LDSMSGNVTM TNPSSSGKSA TWQKSKDLQA 
901:	QAFAHICREN ATSVSKTLPR KRMSSI