Lipid intermediate transporter, Arv1 or pSLC.ARV1, of 271 aas and 4 - 6 TMSs. It plays a role as a mediator of ER cholesterol and bile acid homeostasis (Tinkelenberg et al. 2000, Swain et al. 2002) and participates in sterol transport out of the ER and distribution into plasma membranes (Tong et al. 2010). Defects in the arv1 gene give rise to developmental delay, intellectual disability, seizures, walking and speech impairments, as well as with a dilated cardiomyopathy (DCM) (Karabinos et al. 2022).