9.B.104.1.6
Mitochondrial PARL rhomboid protease of 379 aas. Required for the control of apoptosis
during postnatal growth. Essential for proteolytic processing of an
antiapoptotic form of OPA1 which prevents the release of mitochondrial
cytochrome c in response to intrinsic apoptoptic signals. Impaired in Parkinson Disease (Meissner et al. 2015).
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| Accession Number: | Q9H300 |
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| Protein Name: | Presenilins-associated rhomboid-like protein, mitochondrial |
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| Length: | 379 |
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| Molecular Weight: | 42190.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Nucleus1 |
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| Substrate |
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1: MAWRGWAQRG WGCGQAWGAS VGGRSCEELT AVLTPPQLLG RRFNFFIQQK CGFRKAPRKV
61: EPRRSDPGTS GEAYKRSALI PPVEETVFYP SPYPIRSLIK PLFFTVGFTG CAFGSAAIWQ
121: YESLKSRVQS YFDGIKADWL DSIRPQKEGD FRKEINKWWN NLSDGQRTVT GIIAANVLVF
181: CLWRVPSLQR TMIRYFTSNP ASKVLCSPML LSTFSHFSLF HMAANMYVLW SFSSSIVNIL
241: GQEQFMAVYL SAGVISNFVS YVGKVATGRY GPSLGASGAI MTVLAAVCTK IPEGRLAIIF
301: LPMFTFTAGN ALKAIIAMDT AGMILGWKFF DHAAHLGGAL FGIWYVTYGH ELIWKNREPL
361: VKIWHEIRTN GPKKGGGSK