TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*9.B.169.1.1









9 or 10 TMS protein of 402 aas of unknown function with a C-terminal DUF418 domain and a full length YeiB domain, YxaH. The expression of its gene is regulated by two repressors, LmrA and QdoR, which also regulate the lmrAB operon which encodes LmrA as well as the multidrug resistance MFS drug exporter, LmrB (TC# 2.A.1.3.61) (Hirooka and Fujita 2011). Therefore, YxaH could be an MDR pump. Both of the two repressors bind flavonoids which cause them to dissociate from the DNA, promoting induction of gene expression, also consistent with YxaH being an MDR pump.

Bacteria
Firmicutes
YxaH of Bacillus subtilis
*9.B.169.1.2









YeiB of 385 aas and 8 - 10 TMSs with a C-terminal DUF418 domain. It is encoded within an operon: yeiB-folE where FolE is GTP cyclohydrolase I, the first enzyme in the biosynthesis of tetrahydrofolic acid (El Yacoubi et al. 2006). Therefore YeiB could be a transporter of a derivative in the folate biosynthetic pathway (see also TC# 9.B.169.1.1).

Bacteria
Proteobacteria
YeiB of E. coli
*9.B.169.1.3









Uncharacterized protein of 421 aas and 8 TMSs.

Bacteria
Actinobacteria
UP of Cellulomonas fimi
*9.B.169.1.4









Uncharacterized protein of 417 aas and 10 TMSs

Bacteria
Actinobacteria
UP of Sanguibacter keddieii
*9.B.169.1.5









Uncharacterized protein of 361 aas and 10 TMSs.

Bacteria
Bacteroidetes/Chlorobi group
UP of Psychroflexus torquis
*9.B.169.1.6









Uncharacterized protein of 383 aas and 9 TMSs

Bacteria
Firmicutes
UP of Paenibacillus mucilaginosus
*9.B.169.1.7









Uncharacterized protein of 468 aas and 10 TMSs.

Bacteria
Fibrobacteres/Acidobacteria group
UP of Terriglobus saanensis
*9.B.169.1.8









Uncharacterized protein of 432 aas and 10 TMSs

Archaea
Euryarchaeota
UP of Halobiforma lacisalsi
*9.B.169.1.9









Uncharacterized protein of 403 aas and 10 TMSs.

Bacteria
Actinobacteria
UP of Nocardia brasiliensis
*9.B.169.1.10









Uncharacterized protein of 445 aas and 10 TMSs

Bacteria
Actinobacteria
UP of Thermobifida fusca
*9.B.169.1.11









Uncharacterized protein of 309 aas and 8 TMSs

Bacteria
Actinobacteria
UP of Streptosporangium roseum
*9.B.169.1.12









Uncharacterized protein of 392 aas and 10 TMSs

Bacteria
Proteobacteria
UP of Vibrio halioticol
*9.B.169.2.1









Uncharacterized protein of 381 aas and 11 TMSs

Archaea
Euryarchaeota
UP of Methanosarcina acetivorans
*9.B.169.2.2









Uncharacterized protein of 245 aas and 7 TMSs

Archaea
Euryarchaeota
UP of Methanococcus maripaludis
*9.B.169.2.3









Uncharacterized protein, putative acy transferase of 376 aas and 11 TMSs

Bacteria
Bacteroidetes/Chlorobi group
UP of Ignavibacterium album
*9.B.169.2.4









DUF1624 protein of 260 aas and 8 TMSs.

Archaea
Euryarchaeota
DUF1624 of Methanobacterium formicicum
*9.B.169.2.5









Uncharacterized protein of 394 aas and 11 TMSs

Bacteria
Bacteroidetes/Chlorobi group
UP of Zobellia galactanivorans
*9.B.169.3.1









Uncharacterized protein of 376 aas and 10 TMSs

Bacteria
Proteobacteria
UP of Enhygromyxa salina
*9.B.169.3.2









Uncharacterized protein of 364 aas and 10 TMSs in a 5 + 5 arrangement.

Bacteria
Proteobacteria
UP of Sorangiineae bacterium
*9.B.169.3.3









Uncharacterized protein of 400 aas and 10 TMSs in an apparent 3 + 2 + 3 + 2 arrangement.

Bacteria
Chloroflexi
UP of Chloroflexi bacterium HGW-Chloroflexi-5
*9.B.169.3.4









DUF418 acyltransferase family protein of 375 aas and 10 TMSs.

Archaea
Candidatus Lokiarchaeota
DUF418 protein of Lokiarchaeum sp. GC14_75
*9.B.169.3.5









Uncharacterized acyltransferase family protein of 373 aas and 10 TMSs. similar to its paralogue with TC# 9.B.169.3.4. The two proteins are encoded by two adject genes on the archaeal chromosome.

Archaea
Candidatus Lokiarchaeota
UP of Lokiarchaeum sp. GC14_75
*9.B.169.4.1









Heparana α-glucosaminide N-acetyltransferase, HGSNAT or MEM76.  Of 663 aas and 12 TMSs in a 1 + 1 + 5 + 5 TMS arrangement.  Mutations cause mucopolysaccharidosis 3C (Fan et al. 2006).  This lysosomal acetyltransferase acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase (Durand et al. 2010).

Eukaryota
Metazoa
*9.B.169.4.2









Uncharacterized DUF5009 protein of 373 aas and 10 TMSs in a 5 + 5 arrangement.

Bacteria
Bacteroidetes
UP of Bacteroides cellulosilyticus
*9.B.169.4.3









Uncharacterized DUF5009 protein of 442 aas and 10 TMSs in a 5 + 5 arrangement.

Bacteria
Actinobacteria
UP of Mobiluncus mulieris
*9.B.169.4.4









Uncharacterized DUF3009 protein of 418 aas and 10 TMSs in a 5 + 5 arrangement.

Bacteria
Planctomycetes
DUF5009 protein of Singulisphaera acidiphila
*9.B.169.4.5









Uncharacterized but putative heparan-alpha-glucosaminide N-acetyltransferase (annotation) of 395 aas and 10 TMSs.

Bacteria
Proteobacteria
UP of Pseudoalteromonas lipolytica
*9.B.169.4.6









DUF5009 domain-containing proteinof 387 aas and 10 TMSs in a 5 + 5 arrangement.

Bacteria
Verrucomicrobia
DUF5009 of Prosthecobacter debontii