9.B.208.1.1
The Vitamin D3 Receptor, VDR of 427 aas and 0 - 1 TMS. Possibly can insert into the plasma membrane and form a large channel (see family description) (Morrill et al. 2016). It is a dimer with two transmembrane half helices (264K - N276) and 16 cholesterol binding (CRAC/CARC) domains. May function with importin-4 (TC# 1.I.1.1.3) which may also be able to form a transmembrane channel (Morrill et al. 2016).
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| Accession Number: | P11473 |
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| Protein Name: | Vitamin D3 receptor |
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| Length: | 427 |
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| Molecular Weight: | 48289.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Nucleus1 |
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| Substrate |
calciol |
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1: MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR SMKRKALFTC
61: PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV QRKREMILKR KEEEALKDSL
121: RPKLSEEQQR IIAILLDAHH KTYDPTYSDF CQFRPPVRVN DGGGSHPSRP NSRHTPSFSG
181: DSSSSCSDHC ITSSDMMDSS SFSNLDLSEE DSDDPSVTLE LSQLSMLPHL ADLVSYSIQK
241: VIGFAKMIPG FRDLTSEDQI VLLKSSAIEV IMLRSNESFT MDDMSWTCGN QDYKYRVSDV
301: TKAGHSLELI EPLIKFQVGL KKLNLHEEEH VLLMAICIVS PDRPGVQDAA LIEAIQDRLS
361: NTLQTYIRCR HPPPGSHLLY AKMIQKLADL RSLNEEHSKQ YRCLSFQPEC SMKLTPLVLE
421: VFGNEIS