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Frataxin (Fxn; FrdA) of 210 aas. Defective in the inherited neuro- and cardio-degenerative disease, Friedreich's ataxia (FA), caused by the deficient expression of frataxin that leads to deleterious alterations in iron metabolism (Chiang et al. 2016).

Frataxin of Homo sapiens (Q16595)

Frataxin homologue, Yfh1, of 174 aas.  Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. It also plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+. It can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization and may be involved in the regulation of the mitochondrial electron transport chain (Karlberg et al. 2006).

Yfh1 of Saccharomyces cerevisiae (Baker's yeast)

The CyaY protein of 106 aas is an iron transport protein for iron-sulfur (Fe-S) cluster biosynthetic systems (Uchida et al. 2017). It also transports iron to ferrochelatase that catalyzes insertion of Fe2+ into protoporphyrin IX. Uchida et al. 2017 found that CyaY has the ability to bind heme as well as iron.

CyaY of E. coli (P27838)