TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.B.214.1.2
Surfeit locus protein 4 of 269 aas and 8 predicted TMSs, Surf-4. It has amplification and increased expression in the tumor tissues of several human cancer patients. Overexpression of SURF4 led to increased cell proliferation, migration, and maintenance of anchorage-independent growth. In addition, NIH3T3 cells overexpressing SURF4 induced tumor growth in mice (Kim et al. 2018).

Accession Number:O15260
Protein Name:Surfeit locus protein 4
Length:269
Molecular Weight:30394.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MGQNDLMGTA EDFADQFLRV TKQYLPHVAR LCLISTFLED GIRMWFQWSE QRDYIDTTWN 
61:	CGYLLASSFV FLNLLGQLTG CVLVLSRNFV QYACFGLFGI IALQTIAYSI LWDLKFLMRN 
121:	LALGGGLLLL LAESRSEGKS MFAGVPTMRE SSPKQYMQLG GRVLLVLMFM TLLHFDASFF 
181:	SIVQNIVGTA LMILVAIGFK TKLAALTLVV WLFAINVYFN AFWTIPVYKP MHDFLKYDFF 
241:	QTMSVIGGLL LVVALGPGGV SMDEKKKEW