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9.B.216.1.4
MICOS complex component, MIC60, of 758 aas and 1 N-terminal TMS. It is a determining factor for membrane curvature with the formation of cristae (Tarasenko et al. 2017).  Homologues of this protein are found in α-proteobacteria, the persumed evolutionary source of this mitochondrial protein (Alkhaja et al. 2012). It may catalyze transfer of lipids from the membranes of mitochondra to those of other organelles.  At the ultrastructural level, mutant mitochondria display loss of inner membrane organization. MINOS1/Mio10 in yeast is a constituent of Mitofilin/Fcj1 complexes in both human and yeast mitochondria (Alkhaja et al. 2012). In human mitochondria, the inner membrane MICOS complex interacts with the outer membrane sorting and assembly machinery (SAM) complex, to form the mitochondrial intermembrane space bridging complex (MIB) (Ott et al. 2015). May play a role in mitochondrial division (Cho et al. 2017).

Accession Number:Q16891
Protein Name:MICOS complex subunit MIC60
Length:758
Molecular Weight:83678.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Single-pass membrane protein2
Substrate NONE

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG 
61:	TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE 
121:	SKQPASQLQK QKGDTPASAT APTEAAQIIS AAGDTLSVPA PAVQPEESLK TDHPEIGEGK 
181:	PTPALSEEAS SSSIRERPPE EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA 
241:	AQNAAVQAVN AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE 
301:	ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS EAKVVSQYHE 
361:	LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD LNSLIAHAHR RIDQLNRELA 
421:	EQKATEKQHI TLALEKQKLE EKRAFDSAVA KALEHHRSEI QAEQDRKIEE VRDAMENEMR 
481:	TQLRRQAAAH TDHLRDVLRV QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN 
541:	TAYARLRGIE QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK 
601:	ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE TRNSLYQYFL 
661:	SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH GDLELAAKFV NQLKGESRRV 
721:	AQDWLKEARM TLETKQIVEI LTAYASAVGI GTTQVQPE