9.B.278.1.2
Golgi/endosome-localizing monomeric clathrin adaptors, GGAs. GGA1 is of 639 aas and is a gamma-adaptin ear-containing, ADP ribosylation factor [Arf]-binding protein. The family is ubiquitously expressed Arf-dependent monomeric clathrin adaptor proteins that are conserved from yeast to humans. Mammals have three GGAs (GGA1-3) that work not only at the trans-Golgi network, but also in endosomes to sort transmembrane cargo proteins such as mannose 6-phosphate receptors, sortilin, beta-site amyloid precursor protein cleaving enzyme 1, and epidermal growth factor receptor (Uemura and Waguri 2019).
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| Accession Number: | Q9UJY5 |
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| Protein Name: | ADP-ribosylation factor-binding protein GGA1 |
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| Length: | 639 |
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| Molecular Weight: | 70384.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Golgi apparatus1 / Peripheral membrane protein2 |
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| Substrate |
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1: MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL LAHKIQSPQE
61: WEAIQALTVL ETCMKSCGKR FHDEVGKFRF LNELIKVVSP KYLGSRTSEK VKNKILELLY
121: SWTVGLPEEV KIAEAYQMLK KQGIVKSDPK LPDDTTFPLP PPRPKNVIFE DEEKSKMLAR
181: LLKSSHPEDL RAANKLIKEM VQEDQKRMEK ISKRVNAIEE VNNNVKLLTE MVMSHSQGGA
241: AAGSSEDLMK ELYQRCERMR PTLFRLASDT EDNDEALAEI LQANDNLTQV INLYKQLVRG
301: EEVNGDATAG SIPGSTSALL DLSGLDLPPA GTTYPAMPTR PGEQASPEQP SASVSLLDDE
361: LMSLGLSDPT PPSGPSLDGT GWNSFQSSDA TEPPAPALAQ APSMESRPPA QTSLPASSGL
421: DDLDLLGKTL LQQSLPPESQ QVRWEKQQPT PRLTLRDLQN KSSSCSSPSS SATSLLHTVS
481: PEPPRPPQQP VPTELSLASI TVPLESIKPS NILPVTVYDQ HGFRILFHFA RDPLPGRSDV
541: LVVVVSMLST APQPIRNIVF QSAVPKVMKV KLQPPSGTEL PAFNPIVHPS AITQVLLLAN
601: PQKEKVRLRY KLTFTMGDQT YNEMGDVDQF PPPETWGSL