9.B.278.1.3
GGA3, a paralog of GGA1 (TC# 9.B.278.1.2) of 723 aas with 50% identity with GGA1 (Uemura and Waguri 2019). It plays a role in protein sorting and trafficking
between the trans-Golgi network (TGN) and endosomes and mediates the
ARF-dependent recruitment of clathrin to the TGN. It binds ubiquitinated
proteins and membrane cargo molecules with a cytosolic acidic
cluster-dileucine (DXXLL) motif (PubMed Puertollano et al. 2001). It also mediates export of the GPCR receptor ADRA2B to the cell surface (Zhang et al. 2016). It is involved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (Tesco et al. 2007, He et al. 2005, Kang et al. 2010). Finally it regulates retrograde transport of BACE1 from endosomes to the
trans-Golgi network via interaction through the VHS motif, dependent
of BACE1 phosphorylation (He et al. 2005). The N-terminal 200 residue region resembles (e-6) that of ESCRT-III family protein P38753 in TC# 3.A.31.1.1.
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| Accession Number: | Q9NZ52 |
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| Protein Name: | ADP-ribosylation factor-binding protein GGA3 |
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| Length: | 723 |
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| Molecular Weight: | 78315.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Golgi apparatus1 / Peripheral membrane protein2 |
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| Substrate |
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1: MAEAEGESLE SWLNKATNPS NRQEDWEYII GFCDQINKEL EGPQIAVRLL AHKIQSPQEW
61: EALQALTVLE ACMKNCGRRF HNEVGKFRFL NELIKVVSPK YLGDRVSEKV KTKVIELLYS
121: WTMALPEEAK IKDAYHMLKR QGIVQSDPPI PVDRTLIPSP PPRPKNPVFD DEEKSKLLAK
181: LLKSKNPDDL QEANKLIKSM VKEDEARIQK VTKRLHTLEE VNNNVRLLSE MLLHYSQEDS
241: SDGDRELMKE LFDQCENKRR TLFKLASETE DNDNSLGDIL QASDNLSRVI NSYKTIIEGQ
301: VINGEVATLT LPDSEGNSQC SNQGTLIDLA ELDTTNSLSS VLAPAPTPPS SGIPILPPPP
361: QASGPPRSRS SSQAEATLGP SSTSNALSWL DEELLCLGLA DPAPNVPPKE SAGNSQWHLL
421: QREQSDLDFF SPRPGTAACG ASDAPLLQPS APSSSSSQAP LPPPFPAPVV PASVPAPSAG
481: SSLFSTGVAP ALAPKVEPAV PGHHGLALGN SALHHLDALD QLLEEAKVTS GLVKPTTSPL
541: IPTTTPARPL LPFSTGPGSP LFQPLSFQSQ GSPPKGPELS LASIHVPLES IKPSSALPVT
601: AYDKNGFRIL FHFAKECPPG RPDVLVVVVS MLNTAPLPVK SIVLQAAVPK SMKVKLQPPS
661: GTELSPFSPI QPPAAITQVM LLANPLKEKV RLRYKLTFAL GEQLSTEVGE VDQFPPVEQW
721: GNL