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9.B.39.1.1
CD36 antigen; plasma membrane fatty acid transporter (Schwenk et al. 2010). Also called the scavenger receptor protein as it binds many ligands including both Gram-positive and Gram-negative bacteria; plays a role in immune development (Liu et al. 2016). Direct interaction of CD36 with glycerol phospholipids has been demonstrated (Tsuzuki et al. 2017). CD36 plays a role in the perception of specific odour-active volatile compounds including oleic aldehyde (cis-9-octadecenal), in the nasal cavity (Lee et al. 2017). Jay et al. 2020 have concluded that LCFAs diffuse rapidly across biological membranes and do not require an active protein transporter such as CD36 for their transmembrane movement.

Accession Number:Q08857
Protein Name:CD36
Length:472
Molecular Weight:52698.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate fatty acids

Cross database links:

Genevestigator: Q08857
eggNOG: roNOG12579
HEGENOM: HBG445256
RefSeq: NP_001153027.1    NP_001153028.1    NP_001153029.1    NP_001153030.1    NP_031669.3   
Entrez Gene ID: 12491   
Pfam: PF01130   
KEGG: mmu:12491   

Gene Ontology

GO:0009897 C:external side of plasma membrane
GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0045121 C:membrane raft
GO:0051636 F:Gram-negative bacterial cell surface binding
GO:0051637 F:Gram-positive bacterial cell surface binding
GO:0008035 F:high-density lipoprotein binding
GO:0008289 F:lipid binding
GO:0070892 F:lipoteichoic acid receptor activity
GO:0005041 F:low-density lipoprotein receptor activity
GO:0043277 P:apoptotic cell clearance
GO:0007155 P:cell adhesion
GO:0071221 P:cellular response to bacterial lipopeptide
GO:0071222 P:cellular response to lipopolysaccharide
GO:0071223 P:cellular response to lipoteichoic acid
GO:0030301 P:cholesterol transport
GO:0050830 P:defense response to Gram-positive bacterium
GO:0019915 P:lipid storage
GO:0042159 P:lipoprotein catabolic process
GO:0034381 P:lipoprotein particle clearance
GO:0042953 P:lipoprotein transport
GO:0044130 P:negative regulation of growth of symbiont i...
GO:0006910 P:phagocytosis, recognition
GO:0010886 P:positive regulation of cholesterol storage
GO:0043123 P:positive regulation of I-kappaB kinase/NF-k...
GO:0032735 P:positive regulation of interleukin-12 produ...
GO:0032755 P:positive regulation of interleukin-6 produc...
GO:0060907 P:positive regulation of macrophage cytokine ...
GO:0010744 P:positive regulation of macrophage derived f...
GO:0043410 P:positive regulation of MAPKKK cascade
GO:0060100 P:positive regulation of phagocytosis, engulf...
GO:0032760 P:positive regulation of tumor necrosis facto...

References (2)

[1] “CD36 is a receptor for oxidized low density lipoprotein.”  Endemann G.et.al.   7685021
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKR EVVLEEGTTA FKNWVKTGTT 
61:	VYRQFWIFDV QNPDDVAKNS SKIKVKQRGP YTYRVRYLAK ENITQDPEDH TVSFVQPNGA 
121:	IFEPSLSVGT EDDNFTVLNL AVAAAPHIYQ NSFVQVVLNS LIKKSKSSMF QTRSLKELLW 
181:	GYKDPFLSLV PYPISTTVGV FYPYNDTVDG VYKVFNGKDN ISKVAIIESY KGKRNLSYWP 
241:	SYCDMINGTD AASFPPFVEK SRTLRFFSSD ICRSIYAVFG SEIDLKGIPV YRFVLPANAF 
301:	ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS PDVSEPIEGL 
361:	HPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE ALKNLKRPYI VPILWLNETG 
421:	TIGDEKAEMF KTQVTGKIKL LGMVEMALLG IGVVMFVAFM ISYCACKSKN GK