TCDB is operated by the Saier Lab Bioinformatics Group


9.B.49 The Unknown IT-2 (UIT2) Family

The UIT2 family is a constituent of the IT superfamily (Lolkema and Slotboom, 2003; Prakash et al., 2003; Rabus et al., 1999). It is the st311/AitB family of Lolkema and Slotboom (2003). It consists of proteins from Gram-negative and Gram-positive bacteria (e.g., Fusobacterium, Clostridium, Bacillus, Azotobacter, Pseudomonas species, etc.). These transporters probably transport short chain aliphatic acids such as propionate, butyrate, and β-hydroxybutyrate. The proteins are of about 450 aas with 11-12 putative TMSs. Closest functionally-characterized homologues are in the GntP (TC #2.A.8) family.


This family belongs to the: IT Superfamily.

References associated with 9.B.49 family:

Lolkema, J.S. (2006). Domain structure and pore loops in the 2-hydroxycarboxylate transporter family. J. Mol. Microbiol. Biotechnol. 11: 318-325. 17114896
Lolkema, J.S. and D.-J. Slotboom. (2003). Classification of 29 families of secondary transport proteins into a single structural class using hydropathy profile analysis. J. Mol. Biol. 327: 901-909. 12662917
Prakash, S., G. Cooper, S. Singhi, and M.H. Saier, Jr. (2003). The ion transporter superfamily. Biochim. Biophys. Acta 1618: 79-92. 14643936
Rabus, R., D.L. Jack, D.J. Kelly and M.H. Saier, Jr. (1999). TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters. Microbiology 145: 3431-3445. 10627041