9.B.49 The Unknown IT-2 (UIT2) Family
The UIT2 family is a constituent of the IT superfamily (Lolkema and Slotboom, 2003; Prakash et al., 2003; Rabus et al., 1999). It is the st311/AitB family of Lolkema and Slotboom (2003). It consists of proteins from Gram-negative and Gram-positive bacteria (e.g., Fusobacterium, Clostridium, Bacillus, Azotobacter and Pseudomonas species). These transporters probably transport short chain aliphatic acids such as propionate, butyrate, and β-hydroxybutyrate. The proteins are of about 450 aas with 11-12 putative TMSs. Closest functionally-characterized homologues are in the GntP (TC #2.A.8) family.