9.B.50 The Unknown IT-3 (UIT3) Family
The UIT3 family is a constituent of the IT superfamily (Lolkema and Slotboom, 2003; Prakash et al., 2003; Rabus et al., 1999). It is the st313/AitC family of Lolkema and Slotboom (2003). It consists of proteins from Gram-negative and Gram-positive bacteria (e.g., Streptococcus, Escherichia, Salmonella, Fusobacterium and Borrelia species). The proteins are of about 480 aas with 10-12 putative TMSs. Closest functionally-characterized homologues are in the DcuC (TC #2.A.61) and ArsB (TC #2.A.4) families.
This family belongs to the: IT Superfamily.
References associated with 9.B.50 family:
Lolkema, J.S. (2006). Domain structure and pore loops in the 2-hydroxycarboxylate transporter family. J. Mol. Microbiol. Biotechnol. 11: 318-325. 17114896
Lolkema, J.S. and D.-J. Slotboom. (2003). Classification of 29 families of secondary transport proteins into a single structural class using hydropathy profile analysis. J. Mol. Biol. 327: 901-909. 12662917
Prakash, S., G. Cooper, S. Singhi, and M.H. Saier, Jr. (2003). The ion transporter superfamily. Biochim. Biophys. Acta 1618: 79-92. 14643936
Rabus, R., D.L. Jack, D.J. Kelly and M.H. Saier, Jr. (1999). TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters. Microbiology 145: 3431-3445. 10627041
