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9.B.87 The Selenoprotein P Receptor (SelP-Receptor) Family

Selenoprotein P (SelP) contains most of the selenium in blood plasma, and it is utilized by the kidney, brain and testis as a selenium source for selenoprotein synthesis. Apolipoprotein E receptor-2 (ApoER2) is required for SelP uptake by the testis, and deletion of ApoER2 reduces testis and brain, but not kidney, selenium levels. Neither the C-terminus selenocysteine-rich domain of SelP nor ApoER2 were required for SelP uptake by proximal tubules. SelP binds megalin, a lipoprotein receptor localized to the proximal tubule epithelium. Proximal tubules don't take up SelP in megalin null mice. Thus, kidney selenium homeostasis is mediated by a megalin-dependent SelP uptake pathway in the proximal tubule (Olson et al., 2008) that may use an endocytic mechanism (Thévenod, 2010).

References associated with 9.B.87 family:

and Thevenod F. (2010). Catch me if you can! Novel aspects of cadmium transport in mammalian cells. Biometals. 23(5):857-75. 20204475
Andersen, O.M., J. Reiche, V. Schmidt, M. Gotthardt, R. Spoelgen, J. Behlke, C.A. von Arnim, T. Breiderhoff, P. Jansen, X. Wu, K.R. Bales, R. Cappai, C.L. Masters, J. Gliemann, E.J. Mufson, B.T. Hyman, S.M. Paul, A. Nykjaer, and T.E. Willnow. (2005). sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. USA 102: 13461-13466. 16174740
Bachmann, A., M. Schneider, E. Theilenberg, F. Grawe, and E. Knust. (2001). Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature 414: 638-643. 11740560
Brütsch, R., S.S. Liebler, J. Wüstehube, A. Bartol, S.E. Herberich, M.G. Adam, A. Telzerow, H.G. Augustin, and A. Fischer. (2010). Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. Circ Res 107: 592-601. 20616313
daSilva, L.L., O. Foresti, and J. Denecke. (2006). Targeting of the plant vacuolar sorting receptor BP80 is dependent on multiple sorting signals in the cytosolic tail. Plant Cell 18: 1477-1497. 16714388
Eggert, S., C. Thomas, S. Kins, and G. Hermey. (2018). Trafficking in Alzheimer''s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin. Mol Neurobiol 55: 5809-5829. 29079999
Jobst-Schwan, T., K.X. Knaup, R. Nielsen, T. Hackenbeck, M. Buettner-Herold, P. Lechler, S. Kroening, M. Goppelt-Struebe, U. Schloetzer-Schrehardt, B.G. Fürnrohr, R.E. Voll, K. Amann, K.U. Eckardt, E.I. Christensen, and M.S. Wiesener. (2013). Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule. Am. J. Physiol. Renal Physiol 305: F734-744. 23825075
Kinoshita, A., T. Shah, M.M. Tangredi, D.K. Strickland, and B.T. Hyman. (2003). The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65. J. Biol. Chem. 278: 41182-41188. 12888553
Klar, J., J. Schuster, T.N. Khan, M. Jameel, K. Mäbert, L. Forsberg, S.A. Baig, S.M. Baig, and N. Dahl. (2015). Whole exome sequencing identifies LRP1 as a pathogenic gene in autosomal recessive keratosis pilaris atrophicans. J Med Genet 52: 599-606. 26142438
Klassen, R.B., K. Crenshaw, R. Kozyraki, P.J. Verroust, L. Tio, S. Atrian, P.L. Allen, and T.G. Hammond. (2004). Megalin mediates renal uptake of heavy metal metallothionein complexes. Am. J. Physiol. Renal Physiol 287: F393-403. 15126248
Kole, M.J., J. Qian, M.P. Waase, T.L. Klassen, T.T. Chen, G.J. Augustine, and J.L. Noebels. (2015). Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J. Neurosci. 35: 11433-11444. 26269648
Kounnas, M.Z., R.E. Morris, M.R. Thompson, D.J. FitzGerald, D.K. Strickland, and C.B. Saelinger. (1992). The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J. Biol. Chem. 267: 12420-12423. 1618748
May, P. and J. Herz. (2003). LDL receptor-related proteins in neurodevelopment. Traffic 4: 291-301. 12713657
May, P., Y.K. Reddy, and J. Herz. (2002). Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J. Biol. Chem. 277: 18736-18743. 11907044
Olson, G.E., V.P. Winfrey, K.E. Hill, and R.F. Burk. (2008). Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells. J. Biol. Chem. 283(11): 6854-6860. 18174160
Polacheck, W.J., M.L. Kutys, J. Yang, J. Eyckmans, Y. Wu, H. Vasavada, K.K. Hirschi, and C.S. Chen. (2017). A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature 552: 258-262. 29160307
Pupovac, A. and R. Sluyter. (2016). Roles of extracellular nucleotides and P2 receptors in ectodomain shedding. Cell Mol Life Sci. [Epub: Ahead of Print] 27180276
Saint-Jean, B., E. Seveno-Carpentier, C. Alcon, J.M. Neuhaus, and N. Paris. (2010). The cytosolic tail dipeptide Ile-Met of the pea receptor BP80 is required for recycling from the prevacuole and for endocytosis. Plant Cell 22: 2825-2837. 20807880
Sundararajan, T., A.M. Manzardo, and M.G. Butler. (2018). Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. Gene 641: 25-34. 29032150
Tepass, U., C. Theres, and E. Knust. (1990). crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell 61: 787-799. 2344615
Tufail, M. and M. Takeda. (2009). Insect vitellogenin/lipophorin receptors: molecular structures, role in oogenesis, and regulatory mechanisms. J Insect Physiol 55: 87-103. 19071131
Yi, S., S. Wang, Q. Zhao, C. Yao, Y. Gu, J. Liu, X. Gu, and S. Li. (2016). miR-sc3, a novel miRNA, promoted Schwann cell proliferation and migration by targeting Astn1. Cell Transplant. [Epub: Ahead of Print] 26786955