TC-SUPERFAMILIES:
ABC1, ABC2, ABC3 Superfamilies
as well as the ECF sub-superfamily are all included within the functional ABC superfamily, TC#3.A.1. Their descriptions and constituent families are presented in paragraphs 3 and 4 of the superfamily description under TC#3.A.1. See (Wang, B., M. Dukarevich, E.I. Sun, M.R. Yen, and M.H. Saier, Jr. (2009). Membrane porters of ATP-binding cassette transport systems are polyphyletic. J. Membr. Biol. 231: 1-10.) for more details.
Aerolysin Superfamily
1.C.3 - The α-Hemolysin Channel-forming Toxin (αHL) Family1.C.4 - The Aerolysin Channel-forming Toxin (Aerolysin) Family
1.C.5 - The Channel-forming ε-toxin (ε-toxin) Family
1.C.13 - The Channel-forming Leukocidin Cytotoxin (Ctx) Family
1.C.14 - The Cytohemolysin (CHL) Family
1.C.43 - The Earthworm Lysenin Toxin (Lysenin) Family
1.C.74 - The Snake Cytotoxin (SCT) Family
APC Superfamily
Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81; Wong, F.H., J.S. Chen, V. Reddy, J.L. Day, M.A. Shlykov, S.T. Wakabayashi, and M.H. Saier, Jr. (2012). The amino acid-polyamine-organocation superfamily. J. Mol. Microbiol. Biotechnol. 22: 105-113. These proteins have two 5 TMS repeats except for NCS2 and SulP which have two 7 TMS repeats.
2.A.3 - The Amino Acid-Polyamine-Organocation (APC) Family2.A.15 - The Betaine/Carnitine/Choline Transporter (BCCT) Family
2.A.18 - The Amino Acid/Auxin Permease (AAAP) Family
2.A.21 - The Solute:Sodium Symporter (SSS) Family
2.A.22 - The Neurotransmitter:Sodium Symporter (NSS) Family
2.A.25 - The Alanine or Glycine:Cation Symporter (AGCS) Family
2.A.30 - The Cation-Chloride Cotransporter (CCC) Family
2.A.39 - The Nucleobase:Cation Symporter-1 (NCS1) Family
2.A.40 - The Nucleobase:Cation Symporter-2 (NCS2) Family
2.A.42 - The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family
2.A.53 - The Sulfate Permease (SulP) Family
Bacterial Bacteriocin (BB) Superfamily
*1.C.53 is also shared with the CBB Superfamily
1.C.22 - The Lactococcin A (Lactococcin A) Family1.C.24 - The Pediocin (Pediocin) Family
1.C.26 - The Lactacin X (Lactacin X) Family
1.C.27 - The Divergicin A (Divergicin A) Family
1.C.30 - The Plantaricin JK (Plantaricin JK) Family
1.C.53 - The Lactocyclicin Q (Lactocyclicin Q) Family
1.C.102 - The Cerein (Cerein) Family
BART Superfamily
Mansour, N.M., Sawhney, M., Tamang, D.G., Vogl, C., Saier, M.H. Jr. 2007. The bile/arsenite/riboflavin transporter (BART) superfamily. FEBS Journal 274(3):612-29.
2.A.28 - The Bile Acid:Na+ Symporter (BASS) Family2.A.59 - The Arsenical Resistance-3 (ACR3) Family
2.A.69 - The Auxin Efflux Carrier (AEC) Family
2.A.87 - The Prokaryotic Riboflavin Transporter (P-RFT) Family
2.A.93 - The Unknown BART Superfamily-1 (UBS1) Family
9.B.33 - The Sensor Histidine Kinase (SHK) Family
9.B.34 - The Kinase/Phosphatase/Cyclic-GMP Synthase/Cyclic di-GMP Hydrolase (KPSH) Family
Cation Diffusion Facilitator (CDF) Superfamily
1.A.52 - The Ca2+ Release-activated Ca2+ (CRAC) Channel (CRAC-C) Family2.A.4 - The Cation Diffusion Facilitator (CDF) Family
2.A.19 - The Ca2+:Cation Antiporter (CaCA) Family
2.A.103 - The Bacterial Murein Precursor Exporter (MPE) Family
Cecropin Superfamily
This superfamily may be related to the Melittin superfamily.
1.C.17 - The Cecropin (Cecropin) Family1.C.52 - The Dermaseptin (Dermaseptin) Family
1.C.62 - The Pseudopleuronectes americanus (flounder) Pleurocidin (Pleurocidin) Family
1.C.76 - The Pore-forming Maculatin Peptide (Maculatin) Family
Circular Bacterial Bacteriocin (CBB) Superfamily
*1.C.53 is also shared with the BB Superfamily (see BB Superfamily list). Maqueda, M., M. Sánchez-Hidalgo, M. Fernández, M. Montalbán-López, E. Valdivia, and M. Martínez-Bueno. (2008). Genetic features of circular bacteriocins produced by Gram-positive bacteria. FEMS Microbiol. Rev. 32: 2-22.
1.C.28 - The Bacteriocin AS-48 Cyclic Polypeptide (Bacteriocin AS-48) Family1.C.83 - The Gassericin (Gassericin) Family
1.C.84 - The Subtilosin (Subtilosin) Family
1.C.90 - The Carnocyclin A (Carnocyclin) Family
Claudin Superfamily
1.H.1 - The Claudin Tight Junction (Claudin) Family1.H.2 - The Invertebrate PMP22-Claudin (Claudin2) Family
1.A.81 - The Low Affinity Ca2+ Channel (LACC) Family
8.A.16 - The Ca+ Channel Auxiliary Subunit γ1-γ8 (CCAγ) Family
9.A.46 - The Clarin (CLRN) Family
Corynebacterial PorA/PorH Superfamily
1.B.34 - The Corynebacterial Porin A (PorA) Family1.B.59 - The Outer Membrane Porin, PorH (PorH) Family
CPA Superfamily
Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81.
2.A.36 - The Monovalent Cation:Proton Antiporter-1 (CPA1) Family2.A.37 - The Monovalent Cation:Proton Antiporter-2 (CPA2) Family
2.A.70 - The Malonate:Na+ Symporter (MSS) Family
2.A.98 - The Putative Sulfate Exporter (PSE) Family
3.B.1 - The Na+-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family
Defensin Superfamily
1.C.19 - The Defensin (Defensin) Family1.C.45 - The Plant Defensin (Plant Defensin) Family
1.C.47 - The Insect/Fungal Defensin (Insect/Fungal Defensin) Family
1.C.85 - The Pore-Forming β-Defensin (β-Defensin) Family
Drug/Metabolite Transporter (DMT) Superfamily
2.A.7 (32 families)
2.A.7 - The Drug/Metabolite Transporter (DMT) SuperfamilyENaC/P2X Superfamily
1.A.6 (ENaC) and 1.A.7 (P2X receptor) have similar 3-d structures and are likely to be homologous (Kawate et al, 2009; Gonzales et al, 2009)
1.A.6 - The Epithelial Na+ Channel (ENaC) Family1.A.7 - The ATP-gated P2X Receptor Cation Channel (P2X Receptor) Family
Endomembrane Protein-Translocon (EMPT) Superfamily
Bolte, K., N. Gruenheit, G. Felsner, M.S. Sommer, U.G. Maier, and F. Hempel. (2011). Making new out of old: recycling and modification of an ancient protein translocation system during eukaryotic evolution. Mechanistic comparison and phylogenetic analysis of ERAD, SELMA and the peroxisomal importomer. Bioessays 33: 368-376.
3.A.16 - The Endoplasmic Reticular Retrotranslocon (ER-RT) Family3.A.20 - The Peroxisomal Protein Importer (PPI) Family
3.A.25 - The Symbiont-specific ERAD-like Machinery (SELMA) Family
Gap Junction (GJ) Superfamily
1.A.24 - The Gap Junction-forming Connexin (Connexin) Family1.A.25 - The Gap Junction-forming Innexin (Innexin) Family
General Bacterial Porin (GBP) Superfamily
1.B.1 - The General Bacterial Porin (GBP) Family1.B.7 - The Rhodobacter PorCa Porin (RPP) Family
Holin Superfamily II
1.E.1 - The P21 Holin S (P21 Holin) Family1.E.6 - The T7 Holin (T7 Holin) Family
1.E.7 - The HP1 Holin (HP1 Holin) Family
1.E.25 - The Pseudomonas phage F116 Holin (F116 Holin) Family
Holin Superfamily III
1.E.2 - The λ Holin S (λ Holin) Family1.E.3 - The P2 Holin TM (P2 Holin) Family
1.E.4 - The LydA Holin (LydA Holin) Family
1.E.5 - The PRD1 Phage P35 Holin (P35 Holin) Family
1.E.20 - The Pseudomonas aeruginosa Hol Holin (Hol Holin) Family
1.E.34 - The Putative Actinobacterial Holin-X (Hol-X) Family
1.E.41 - The Deinococcus/Thermus Holin (D/T-Hol) Family
Holin Superfamily IV
1.E.10 - The Bacillus subtilis φ29 Holin (φ29 Holin) Family1.E.16 - The Cph1 Holin (Cph1 Holin) Family
1.E.19 - The Clostridium difficile TcdE Holin (TcdE Holin) Family
1.E.40 - The Mycobacterial 4 TMS Phage Holin (MP4 Holin) Family
Holin Superfamily V
1.E.21 - The Listeria Phage A118 Holin (Hol118) Family1.E.29 - The Holin Hol44 (Hol44) Family
Holin Superfamily VI
1.E.12 - The φAdh Holin (φAdh Holin) Family1.E.26 - The Holin LLH (Holin LLH) Family
Huwentoxin Superfamily
Diao, J., Lin, Y., Tang, J., and Liang, S. (2003). cDNA sequence analysis of seven peptide toxins from the spider Selenocosmia huwena. Toxicon 42: 715-723.
8.B.3 - The Huwentoxin-1 (Huwentoxin-1) Family8.B.5 - The Na+/K+/Ca2+ Channel Targeting Tarantula Huwentoxin (THT) Family
IT Superfamily
Prakash S, Cooper G, Singhi S, Saier MH. The ion transporter superfamily. Biochim Biophys Acta. 2003 Dec 3;1618(1):79-92.
2.A.8 - The Gluconate:H+ Symporter (GntP) Family2.A.11 - The Citrate-Mg2+:H+ (CitM) Citrate-Ca2+:H+ (CitH) Symporter (CitMHS) Family
2.A.13 - The C4-Dicarboxylate Uptake (Dcu) Family
2.A.14 - The Lactate Permease (LctP) Family
2.A.34 - The NhaB Na+:H+ Antiporter (NhaB) Family
2.A.35 - The NhaC Na+:H+ Antiporter (NhaC) Family
2.A.45 - The Arsenite-Antimonite (ArsB) Efflux Family
2.A.47 - The Divalent Anion:Na+ Symporter (DASS) Family
2.A.56 - The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family
2.A.61 - The C4-dicarboxylate Uptake C (DcuC) Family
2.A.62 - The NhaD Na+:H+ Antiporter (NhaD) Family
2.A.68 - The p-Aminobenzoyl-glutamate Transporter (AbgT) Family
2.A.94 - The Phosphate Permease (Pho1) Family
2.A.101 - The Malonate Uptake (MatC) Family (Formerly UIT1)
9.B.49 - The Unknown IT-2 (UIT2) Family
9.B.50 - The Unknown IT-3 (UIT3) Family
9.B.51 - The Unknown IT-4 (UIT4) Family
9.B.52 - The Unknown IT-5 (UIT5) Family
9.B.54 - The Unknown IT-7 (UIT7) Family
9.B.55 - The Unknown IT-8 (UIT8) Family
9.B.56 - The Unknown IT-9 (UIT9) Family
9.B.57 - The Unknown IT-10 (UIT10) Family
9.B.58 - The Unknown IT-11 (UIT11) Family
LysE Superfamily
Vrljic M, Garg J, Bellmann A, Wachi S, Freudl R, Malecki MJ, Sahm H, Kozina VJ, Eggeling L, Saier MH Jr. The LysE superfamily: topology of the lysine exporter LysE of Corynebacterium glutamicum, a paradyme for a novel superfamily of transmembrane solute translocators. J Mol Microbiol Biotechnol. 1999;1:327-36.
2.A.75 - The L-Lysine Exporter (LysE) Family2.A.76 - The Resistance to Homoserine/Threonine (RhtB) Family
2.A.77 - The Cadmium Resistance (CadD) Family
2.A.99 - The 6TMS Ni2+ uptake transporter (HupE-UreJ) Family
MACPF Superfamily
1.C.12 - Thiol-activated Cholesterol-dependent Cytolysin (CDC) Family1.C.39 - The Membrane Attack Complex/Perforin (MACPF) Family
1.C.97 - The Pleurotolysin pore-forming (Pleurotolysin) Family
Major Intrinsic Protein (MIP) Superfamily
1.A.8 - The Major Intrinsic Protein (MIP) Family1.A.16 - The Formate-Nitrite Transporter (FNT) Family
Melittin Superfamily
This superfamily may be related to the Cecropin superfamily.
1.C.18 - The Melittin (Melittin) Family1.C.32 - The Amphipathic Peptide Mastoparan (Mastoparan) Family
1.C.51 - The Pilosulin (Pilosulin) Family
MFS Superfamily
Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81. Reddy, V.S., M.A. Shlykov, R. Castillo, E.I. Sun, and M.H. Saier, Jr. (2012). The major facilitator superfamily (MFS) revisited. FEBS J. 279: 2022-2035.
2.A.1 - The Major Facilitator Superfamily (MFS)2.A.2 - The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family
2.A.12 - The ATP:ADP Antiporter (AAA) Family
2.A.17 - The Proton-dependent Oligopeptide Transporter (POT) Family
2.A.48 - The Reduced Folate Carrier (RFC) Family
2.A.60 - The Organo Anion Transporter (OAT) Family
2.A.71 - The Folate-Biopterin Transporter (FBT) Family
9.B.111 - The 6TMS Lysyl tRNA synthetase (LysS) Family
Mitochondrial Carrier (MC) Superfamily
2.A.29 (32 families)
2.A.29 - The Mitochondrial Carrier (MC) Family9.B.25 - The Mitochondrial Inner/Outer Membrane Fusion (MMF) Family
MspA Superfamily
1.B.24 - The Mycobacterial Porin (MBP) Family1.B.58 - Nocardial Hetero-oligomeric Cell Wall Channel (NfpA/B) Family
Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily
2.A.66 (12 families)
2.A.66 - The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase SuperfamilyOmpG Superfamily
1.B.21 - The OmpG Porin (OmpG) Family1.B.26 - The Cyclodextrin Porin (CDP) Family
1.B.35 - The Oligogalacturonate-specific Porin (KdgM) Family
Opr Superfamily
1.B.19 - The Glucose-selective OprB Porin (OprB) Family1.B.25 - The Outer Membrane Porin (Opr) Family
P-type ATPase (P-ATPase) Superfamily
3.A.3 (32 families)
3.A.3 - The P-type ATPase (P-ATPase) SuperfamilyPTS-AG Superfamily
Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81.
4.A.5 - The PTS Galactitol (Gat) Family4.A.7 - The PTS L-Ascorbate (L-Asc) Family
PTS-GFL Superfamily
Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81.
Nguyen T.X., Yen M.R., Barabote R.D., Saier M.H. Jr. 2006. Topological predictions for integral membrane permeases of the phosphoenolpyruvate:sugar phosphotransferase system. J Mol Microbiol Biotechnol. 11(6):345-60.
4.A.1 - The PTS Glucose-Glucoside (Glc) Family4.A.2 - The PTS Fructose-Mannitol (Fru) Family
4.A.3 - The PTS Lactose-N,N'-Diacetylchitobiose-β-glucoside (Lac) Family
4.A.4 - The PTS Glucitol (Gut) Family
Resistance-Nodulation-Cell Division (RND) Superfamily
2.A.6 (9 families)
2.A.6 - The Resistance-Nodulation-Cell Division (RND) SuperfamilyRTX-toxin Superfamily
1.C.11 - The Pore-forming RTX Toxin (RTX-toxin) Family1.C.56 - The Pseudomanas syringae HrpZ Target Host Cell Membrane Cation Channel (HrpZ) Family
1.C.57 - The Clostridial Cytotoxin (CCT) Family
TRC/TAMP-B (TRC/TAMP) Superfamily
3.A.19 - The TMS Recognition/Insertion Complex (TRC) Family3.A.21 - The C-terminal Tail-Anchored Membrane Protein Biogenesis/ Insertion Complex (TAMP-B) Family
VIC Superfamily
Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81.
1.A.1 - The Voltage-gated Ion Channel (VIC) Superfamily1.A.2 - Inward Rectifier K+ Channel (IRK-C) Family
1.A.3 - The Ryanodine-Inositol 1,4,5-triphosphate Receptor Ca2+ Channel (RIR-CaC) Family
1.A.4 - The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family
1.A.5 - The Polycystin Cation Channel (PCC) Family
1.A.10 - The Glutamate-gated Ion Channel (GIC) Family of Neurotransmitter Receptors
2.A.38 - The K+ Transporter (Trk) Family
