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TCDB is operated by the Saier Lab Bioinformatics Group
TC-SUPERFAMILIES:

Aerolysin Superfamily

1.C.3 - The α-Hemolysin Channel-forming Toxin (αHL) Family
1.C.4 - The Aerolysin Channel-forming Toxin (Aerolysin) Family
1.C.5 - The Channel-forming ε-toxin (ε-toxin) Family
1.C.13 - The Channel-forming Leukocidin Cytotoxin (Ctx) Family
1.C.14 - The Cytohemolysin (CHL) Family
1.C.43 - The Earthworm Lysenin Toxin (Lysenin) Family
1.C.74 - The Snake Cytotoxin (SCT) Family

APC Superfamily

Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81.

2.A.3 - The Amino Acid-Polyamine-Organocation (APC) Family
2.A.15 - The Betaine/Carnitine/Choline Transporter (BCCT) Family
2.A.18 - The Amino Acid/Auxin Permease (AAAP) Family
2.A.21 - The Solute:Sodium Symporter (SSS) Family
2.A.22 - The Neurotransmitter:Sodium Symporter (NSS) Family
2.A.25 - The Alanine or Glycine:Cation Symporter (AGCS) Family
2.A.30 - The Cation-Chloride Cotransporter (CCC) Family
2.A.39 - The Nucleobase:Cation Symporter-1 (NCS1) Family
2.A.40 - The Nucleobase:Cation Symporter-2 (NCS2) Family
2.A.42 - The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family
2.A.53 - The Sulfate Permease (SulP) Family

Bacterial Bacteriocin (BB) Superfamily

BART Superfamily

Mansour, N.M., Sawhney, M., Tamang, D.G., Vogl, C., Saier, M.H. Jr. 2007. The bile/arsenite/riboflavin transporter (BART) superfamily. FEBS Journal 274(3):612-29.

2.A.28 - The Bile Acid:Na+ Symporter (BASS) Family
2.A.59 - The Arsenical Resistance-3 (ACR3) Family
2.A.69 - The Auxin Efflux Carrier (AEC) Family
2.A.87 - The Prokaryotic Riboflavin Transporter (P-RFT) Family
2.A.93 - The Unknown BART Superfamily-1 (UBS1) Family
9.B.33 - The Sensor Histidine Kinase (SHK) Family
9.B.34 - The Kinase/Phosphatase/Cyclic-GMP Synthase/Cyclic di-GMP Hydrolase (KPSH) Family

Cation Diffusion Facilitator (CDF) Superfamily

1.A.52 - The Ca2+ Release-activated Ca2+ (CRAC) Channel (CRAC-C) Family
2.A.4 - The Cation Diffusion Facilitator (CDF) Family
2.A.19 - The Ca2+:Cation Antiporter (CaCA) Family
2.A.103 - The Bacterial Murein Precursor Exporter (MPE) Family

Cecropin Superfamily

This superfamily may be related to the Melittin superfamily.

1.C.17 - The Cecropin (Cecropin) Family
1.C.52 - The Dermaseptin (Dermaseptin) Family
1.C.62 - The Pseudopleuronectes americanus (flounder) Pleurocidin (Pleurocidin) Family
1.C.76 - The Pore-forming Maculatin Peptide (Maculatin) Family

CPA Superfamily

Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81.

2.A.36 - The Monovalent Cation:Proton Antiporter-1 (CPA1) Family
2.A.37 - The Monovalent Cation:Proton Antiporter-2 (CPA2) Family
2.A.70 - The Malonate:Na+ Symporter (MSS) Family
2.A.98 - The Putative Sulfate Exporter (PSE) Family
3.B.1 - The Na+-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family

Cyclic Bacteriocin Group I (CBGI) Superfamily

Defensin Superfamily

1.C.19 - The Defensin (Defensin) Family
1.C.45 - The Plant Defensin (Plant Defensin) Family
1.C.47 - The Insect/Fungal Defensin (Insect/Fungal Defensin) Family
1.C.85 - The Pore-Forming β-Defensin (β-Defensin) Family

ENaC/P2X Superfamily

1.A.6 (ENaC) and 1.A.7 (P2X receptor) have similar 3-d structures and are likely to be homologous (Kawate et al, 2009; Gonzales et al, 2009)

1.A.6 - The Epithelial Na+ Channel (ENaC) Family
1.A.7 - The ATP-gated P2X Receptor Cation Channel (P2X Receptor) Family

Extended Cyclic Bacteriocin (ECB) Superfamily

1.C.22 - The Lactococcin A (Lactococcin A) Family
1.C.24 - The Pediocin (Pediocin) Family
1.C.26 - The Lactacin X (Lactacin X) Family
1.C.27 - The Divergicin A (Divergicin A) Family
1.C.28 - The Bacteriocin AS-48 Cyclic Polypeptide (Bacteriocin AS-48) Family
1.C.30 - The Plantaricin JK (Plantaricin JK) Family
1.C.31 - The Channel-forming Colicin V (Colicin V) Family
1.C.53 - The Lactocyclicin Q (Lactocyclicin Q) Family
1.C.83 - The Gassericin (Gassericin) Family
1.C.90 - The Carnocyclin A (Carnocyclin) Family
1.C.102 - The Cerein (Cerein) Family

General Bacterial Porin (GBP) Superfamily

1.B.1 - The General Bacterial Porin (GBP) Family
1.B.7 - The Rhodobacter PorCa Porin (RPP) Family

Huwentoxin Superfamily

Diao, J., Lin, Y., Tang, J., and Liang, S. (2003). cDNA sequence analysis of seven peptide toxins from the spider Selenocosmia huwena. Toxicon 42: 715-723.

8.B.3 - The Huwentoxin-1 (Huwentoxin-1) Family
8.B.5 - The Na+/K+/Ca2+ Channel Targeting Tarantula Huwentoxin (THT) Family

IT Superfamily

Prakash S, Cooper G, Singhi S, Saier MH. The ion transporter superfamily. Biochim Biophys Acta. 2003 Dec 3;1618(1):79-92.

2.A.8 - The Gluconate:H+ Symporter (GntP) Family
2.A.11 - The Citrate-Mg2+:H+ (CitM) Citrate-Ca2+:H+ (CitH) Symporter (CitMHS) Family
2.A.13 - The C4-Dicarboxylate Uptake (Dcu) Family
2.A.14 - The Lactate Permease (LctP) Family
2.A.34 - The NhaB Na+:H+ Antiporter (NhaB) Family
2.A.35 - The NhaC Na+:H+ Antiporter (NhaC) Family
2.A.45 - The Arsenite-Antimonite (ArsB) Efflux Family
2.A.47 - The Divalent Anion:Na+ Symporter (DASS) Family
2.A.56 - The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family
2.A.61 - The C4-dicarboxylate Uptake C (DcuC) Family
2.A.62 - The NhaD Na+:H+ Antiporter (NhaD) Family
2.A.68 - The p-Aminobenzoyl-glutamate Transporter (AbgT) Family
2.A.94 - The Phosphate Permease (Pho1) Family
9.B.49 - The Unknown IT-2 (UIT2) Family
9.B.50 - The Unknown IT-3 (UIT3) Family
9.B.51 - The Unknown IT-4 (UIT4) Family
9.B.52 - The Unknown IT-5 (UIT5) Family
9.B.53 - The Unknown IT-6 (UIT6) Family
9.B.54 - The Unknown IT-7 (UIT7) Family
9.B.55 - The Unknown IT-8 (UIT8) Family
9.B.56 - The Unknown IT-9 (UIT9) Family
9.B.57 - The Unknown IT-10 (UIT10) Family
9.B.58 - The Unknown IT-11 (UIT11) Family

LysE Superfamily

Vrljic M, Garg J, Bellmann A, Wachi S, Freudl R, Malecki MJ, Sahm H, Kozina VJ, Eggeling L, Saier MH Jr. The LysE superfamily: topology of the lysine exporter LysE of Corynebacterium glutamicum, a paradyme for a novel superfamily of transmembrane solute translocators. J Mol Microbiol Biotechnol. 1999;1:327-36.

2.A.75 - The L-Lysine Exporter (LysE) Family
2.A.76 - The Resistance to Homoserine/Threonine (RhtB) Family
2.A.77 - The Cadmium Resistance (CadD) Family
2.A.99 - The 6TMS Ni2+ uptake transporter (HupE-UreJ) Family

MACPF Superfamily

1.C.12 - Thiol-activated Cholesterol-dependent Cytolysin (CDC) Family
1.C.39 - The Membrane Attack Complex/Perforin (MACPF) Family
1.C.97 - The Pleurotolysin pore-forming (Pleurotolysin) Family

Melittin Superfamily

This superfamily may be related to the Cecropin superfamily.

1.C.18 - The Melittin (Melittin) Family
1.C.32 - The Amphipathic Peptide Mastoparan (Mastoparan) Family
1.C.51 - The Pilosulin (Pilosulin) Family

Mer Superfamily

1.A.72 - The Mer Superfamily

MFS Superfamily

Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81.

2.A.1 - The Major Facilitator Superfamily (MFS)
2.A.2 - The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family
2.A.12 - The ATP:ADP Antiporter (AAA) Family
2.A.17 - The Proton-dependent Oligopeptide Transporter (POT) Family
2.A.48 - The Reduced Folate Carrier (RFC) Family
2.A.60 - The Organo Anion Transporter (OAT) Family
2.A.71 - The Folate-Biopterin Transporter (FBT) Family

Mitochondrial Carrier (MC) Superfamily

2.A.29 - The Mitochondrial Carrier (MC) Family
9.B.25 - The Mitochondrial Inner/Outer Membrane Fusion (MMF) Family

OmpG Superfamily

1.B.21 - The OmpG Porin (OmpG) Family
1.B.26 - The Cyclodextrin Porin (CDP) Family
1.B.35 - The Oligogalacturonate-specific Porin (KdgM) Family

Opr Superfamily

1.B.19 - The Glucose-selective OprB Porin (OprB) Family
1.B.25 - The Outer Membrane Porin (Opr) Family

PTS-AG Superfamily

Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81.

4.A.5 - The PTS Galactitol (Gat) Family
4.A.7 - The PTS L-Ascorbate (L-Asc) Family

PTS-GFL Superfamily

Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81.

Nguyen T.X., Yen M.R., Barabote R.D., Saier M.H. Jr. 2006. Topological predictions for integral membrane permeases of the phosphoenolpyruvate:sugar phosphotransferase system. J Mol Microbiol Biotechnol. 11(6):345-60.

4.A.1 - The PTS Glucose-Glucoside (Glc) Family
4.A.2 - The PTS Fructose-Mannitol (Fru) Family
4.A.3 - The PTS Lactose-N,N'-Diacetylchitobiose-β-glucoside (Lac) Family
4.A.4 - The PTS Glucitol (Gut) Family

RTX-toxin Superfamily

1.C.11 - The Pore-forming RTX Toxin (RTX-toxin) Family
1.C.56 - The Pseudomanas syringae HrpZ Target Host Cell Membrane Cation Channel (HrpZ) Family
1.C.57 - The Clostridial Cytotoxin (CCT) Family

VIC Superfamily

Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. 2004. Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. Mol Membr Biol. 21(3):171-81.

1.A.1 - The Voltage-gated Ion Channel (VIC) Superfamily
1.A.2 - Inward Rectifier K+ Channel (IRK-C) Family
1.A.3 - The Ryanodine-Inositol 1,4,5-triphosphate Receptor Ca2+ Channel (RIR-CaC) Family
1.A.4 - The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family
1.A.5 - The Polycystin Cation Channel (PCC) Family
1.A.10 - The Glutamate-gated Ion Channel (GIC) Family of Neurotransmitter Receptors
2.A.38 - The K+ Transporter (Trk) Family

YaeT/TpsB Superfamily

1.B.20 - The Two-Partner Secretion (TPS) Family
1.B.33 - The Outer Membrane Protein Insertion Porin (Bam Complex) (OmpIP) Family