Holin I Superfamily

The three subfamilies of 1.E.11 are very distant from each other and therefore can be considered to be separate families. Reddy, B.L. and M.H. Saier, Jr. (2013). Topological and phylogenetic analyses of bacterial holin families and superfamilies. Biochim. Biophys. Acta. 1828: 2654-2671. Holin I Superfamily may be distantly related to Holin VI Superfamily.