TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.6.1.1









Cold-sensitive fermentation (CSF1) protein of 2985 aas.  It is a tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Toulmay et al. 2022). It is required for the uptake of glucose and other nutrients at low temperature (Tokai et al. 2000).

Eukaryota
Fungi, Ascomycota
CSF1 of Saccharomyces cerevisiae
8.A.6.1.2









Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein, Lpd-1 or LPD3, of 4018 aas and at least one N-terminal TMS, but several additional potential TMSs. It is a tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum. It also plays a role in endosomal trafficking and endosome recycling, and is involved in the actin cytoskeleton and cilia structural dynamics (Kane et al. 2019). It acts as a regulator of phagocytosis (Jeng et al. 2019).  The structural basis of bulk lipid transfer by bridge-like lipid transfer protein LPD-3 in C. elegans has been solved (Kang et al. 2024).

Eukaryota
Metazoa, Nematoda
Lpd-1 of Caenorhabditis elegans
8.A.6.1.3









Bridge-like lipid transfer protein family member 1, Bltp1, of 5005 aas with one N-terminal TMS plus possibly additional TMSs elsewhere. It is a tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum, and it plays a role in endosomal trafficking and endosome recycling. It may also be involved in the actin cytoskeleton and cilia structural dynamics (Kane et al. 2019) while also acting as a regulator of phagocytosis (Jeng et al. 2019).

Eukaryota
Metazoa, Chordata
Bltp1 of Homo sapiens
8.A.6.1.4









LPD-3 of 3371 aas with at least one N-terminal TMS and possibly more.  

None
Metazoa, Nematoda
LPD-3 of Pristionchus pacificus