TRANSPORTERS FROM HUMANS:
| Transporter Information: | |
| Name: | sodium channel, nonvoltage-gated 1 alpha |
|---|---|
| Symbol: | SCNN1A |
| TC: | 1.A.6.1.1 |
| Locations: | 12p13 |
| Aliases: | ENaCalpha |
| GenBank: | Z92978 |
| Swiss-Prot: | P37088 |
| Accession Number: | NM_001038 |
| GDB | GDB:366596 |
| LocusLink | 6337 |
| OMIM | 600228 |
| PubMed (7896277): | Meisler MH, Barrow LL, Canessa CM, Rossier BC. SCNN1, an epithelial cell sodium channel gene in the conserved linkage group onmouse chromosome 6 and human chromosome 12.Genomics. 1994 Nov 1;24(1):185-6. PMID: 7896277 [PubMed - indexed for MEDLINE] SCNN1, a gene encoding a nonvoltage-gated sodium channel, was detected using a rat colon cDNA probe with homology to Caenorhabditis elegans degenerin genes. Human SCNN1 was assigned to chromosome 12 using the NIGMS hybrid mapping panel 2. Mouse SCNN1 was mapped to a conserved linkage group on distal chromosome 6. The observed order of mouse genes was centromere-Raf1-(2.1 +/- 2.1)-Scnn1, Vwf-(1.9 +/- 1.9)-Ntf3, with 0/101 recombinants between Scnn1 and Vwf. No rearrangements of genomic DNA were detected in the linked mouse mutations deaf waddler (dfw) and opisthotonus (opt). |
>sp|P37088|SCAA_HUMAN AMILORIDE-SENSITIVE SODIUM CHANNEL ALPHA-SUBUNIT (EPITHELIAL NA+ CHANNEL ALPHA SUBUNIT) (ALPHA ENAC) (NONVOLTAGE-GATED SODIUM CHANNEL 1 ALPHA SUBUNIT) (SCNEA) (ALPHA NACH) - Homo sapiens (Human).
MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHN
RMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFD
LYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT
YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSS
MPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSD
VPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS
VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFG
SSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAP
PPAYATLGPRPSPGGSAGASSSTCPLGGP
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