TRANSPORTERS FROM HUMANS:
| Transporter Information: | |
| Name: | solute carrier family 22 (organic cation transporter), member 13 |
|---|---|
| Symbol: | SLC22A13 |
| Locations: | 3p22-p21.3 |
| Aliases: | OCTL1 |
| GenBank: | AB010438 |
| Accession Number: | NM_004256 |
| Old Name: | organic cationic transporter-like 3 |
| LocusLink | 9390 |
| OMIM | 604047 |
| PubMed (10072596): | Nishiwaki T, Daigo Y, Tamari M, Fujii Y, Nakamura Y. Molecular cloning, mapping, and characterization of two novel human genes,ORCTL3 and ORCTL4, bearing homology to organic-cation transporters.Cytogenet Cell Genet. 1998;83(3-4):251-5. PMID: 10072596 [PubMed - indexed for MEDLINE] Through a large-scale sequencing of genomic DNA at 3p22-->p21.3, we have isolated two human genes (ORCTL3 alias OCTL1 and ORCTL4 alias OCTL2) encoding novel members of the family of organic-cation transporter molecules. The predicted proteins revealed the highest similarities to recently- isolated organic-cation transporter proteins, rat OCT-1r, rat NLT and mouse NKT. The transcripts of both genes were expressed ubiquitously in various human tissues, but some tissue-specific transcripts were also observed in kidney, testis, or skeletal muscle. The two genes are clustered within a 52-kb region of genomic DNA and ORCTL4 lies about 27 kb telomeric to ORCTL3 in the genomic DNA sequence in a tail-to-head orientation. |