| Transporter Information: | |
| Name: | solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 |
|---|---|
| Symbol: | SLC35D1 |
| TC: | 2.A.7.15.2 |
| Locations: | 1p32-p31 |
| Aliases: | UGTREL7, KIAA0260 |
| GenBank: | AB044343 |
| Swiss-Prot: | Q9NTN3 |
| Accession Number: | NM_015139 |
| LocusLink | 23169 |
| PubMed (11322953): | Muraoka M, Kawakita M, Ishida N. Molecular characterization of human UDP-glucuronicacid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporterwith dual substrate specificity.FEBS Lett. 2001 Apr 20;495(1-2):87-93. PMID: 11322953 [PubMed - indexed for MEDLINE] A novel human nucleotide sugar transporter (NST) which transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) has been identified, cloned and characterized. The strategy for the identification of the novel NST involved a search of the expressed sequence tags database for genes related to the human UDP-galactose transporter-related isozyme 1, followed by heterologous expression of a candidate gene (hUGTrel7) in Saccharomyces cerevisiae and biochemical analyses. Significantly more UDP-GlcA and UDP-GalNAc were translocated from the reaction medium into the lumen of microsomes prepared from the hUGTrel7-expressing yeast cells than into the control microsomes from cells not expressing hUGTrel7. The possibility that this transporter participates in glucuronidation and/or chondroitin sulfate biosynthesis is discussed. |
>Q9NTN3|S35D1_HUMAN UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter - Homo sapiens (Human). MAEVHRRQHARVKGEAPAKSSTLRDEEELGMASAETLTVFLKLLAAGFYGVSSFLIVVVNKSVLTNYRFPSSLCVGLGQM VATVAVLWVGKALRVVKFPDLDRNVPRKTFPLPLLYFGNQITGLFSTKKLNLPMFTVLRRFSILFTMFAEGVLLKKTFSW GIKMTVFAMIIGAFVAASSDLAFDLEGYAFILINDVLTAANGAYVKQKLDSKELGKYGLLYYNALFMILPTLAIAYFTGD AQKAVEFEGWADTLFLLQFTLSCVMGFILMYATVLCTQYNSALTTTIVGCIKNILITYIGMVFGGDYIFTWTNFIGLNIS IAGSLVYSYITFTEEQLSKQSEANNKLDIKGKGAV | |