3.A.7.12.1
The Cag pathogenicity island (PAI) proteins (Kutter et al., 2008). CagD (Cag24) is essential for CagA translocation and maximal induction of interleukin-8 secretion (Cendron et al., 2009). It is required for a pro-inflammatory response and multiple cytoskeletal and gene regulatory effects in gastric epithelial cells. Its molecular properties are described in a review by Fischer (2011). Cag16 (CagM) (of unknown function and not dermonstrably homologous to proteins of type IV secretion systems in other bacteria) has 3-4 TMSs and is essential for CagA export. It may therefore be a core protein of the Cag complex (Ling et al. 2013).
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| Accession Number: | A4GMW0 |
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| Protein Name: | Cag2 |
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| Length: | 218 |
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| Molecular Weight: | 25193.00 |
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| Species: | Helicobacter pylori (Campylobacter pylori) [210] |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Lipid-anchor2 |
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| Substrate |
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| Pfam: |
PF01396
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[1] “Microevolution of Helicobacter pylori type IV secretion systems in an ulcer disease patient over a ten-year period.” Alvi A. et.al. 17942650
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1: MSLVTSYSVS NNFSKFNIKR VRGYLICFVC NTPKMIQRGL NGISFYGCSD YVNKGDCKGV
61: LREINGSMKM VCLHCENTPI MEKVESGRGG AYACKNCNRK FYFIDLAKQN ERKKDLEKEK
121: KELLNKIEKQ KIKRLERFIL AGVKANIKEN SFFLGCKNYP KCEWTASMDS QDLKCPKCNR
181: LMKEKNFNNN EFFTATSLTL NAMEFCLHIN LKKKETNV