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3.A.1.134.7
The VraFG ABC transporter interacts with GraXSR [GraX, Q7A2W7; GraS, A6QEW9; GraR, A6QEW8] to form a five- or six-component system required for cationic antimicrobial peptide sensing and resistance (Falord et al., 2012).  VraX has been termed a two component system connector and may not be a component of the transporter. VraFG may be a sensor rather than the transporter for the substrate peptide. The actual transporter regulated by VraFGX may have TC# 4.H.1.1.1 (MprF) (Falord et al. 2012). The extracellular loop of the membrane permease VraG interacts with GraS to sense cationic antimicrobial peptides in Staphylococcus aureus (Cho et al. 2021).

Accession Number:A6QEX0
Protein Name:ABC transporter ATP-binding protein VraF
Length:253
Molecular Weight:28463.00
Species:Staphylococcus aureus (strain Newman) [426430]
Substrate Cationic antimicrobial peptides

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FASTA formatted sequence
1:	MAILEVKQLT KIYGTKKMAQ EVLRDINMSI EEGEFIAIMG PSGSGKTTLL NVLSSIDYIS 
61:	QGSITLKGKK LEKLSNKELS DIRKHDIGFI FQEYNLLHTL TVKENIMLPL TVQKLDKEHM 
121:	LNRYEKVAEA LNILDISDKY PSELSGGQRQ RTSAARAFIT LPSIIFADEP TGALDSKSTQ 
181:	DLLKRLTRMN EAFKSTIIMV THDPVAASYA NRVVMLKDGQ IFTELYQGDD DKHTFFKEII 
241:	RVQSVLGGVN YDL