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3.A.1.134.7
The VraFG ABC transporter interacts with GraXSR [GraX, Q7A2W7; GraS, A6QEW9; GraR, A6QEW8] to form a five- or six-component system required for cationic antimicrobial peptide sensing and resistance (Falord et al., 2012).  VraX has been termed a two component system connector and may not be a component of the transporter. VraFG may be a sensor rather than the transporter for the substrate peptide. The actual transporter regulated by VraFGX may have TC# 4.H.1.1.1 (MprF) (Falord et al. 2012). The extracellular loop of the membrane permease VraG interacts with GraS to sense cationic antimicrobial peptides in Staphylococcus aureus (Cho et al. 2021).

Accession Number:A6QEX1
Protein Name:ABC-type transport system permease component VraG
Length:633
Molecular Weight:72161.00
Species:Staphylococcus aureus (strain Newman) [426430]
Number of TMSs:10
Substrate Cationic antimicrobial peptides

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FASTA formatted sequence
1:	MALIMTFNEI IFKNFRQNLS HYAIYLFSLI TSVVLYFSFV ALKYAHKLNM TESYPIIKEG 
61:	SQVGSYFLFF IIIAFLLYAN VLFIKRRSYE LALYQTLGLS KFNIIYILML EQLLIFIITA 
121:	ILGIIIGIFG SKLLLMIVFT LLGIKEKVPI IFSLRAVFET LMLIGVAYFL TSAQNFILVF 
181:	KQSISQMSKN NQVKETNHNK ITFEEVVLGI LGIVLITTGY YLSLNIVQYY DSIGTLMFIL 
241:	LSTVIGAYLF FKSSVSLVFK MVKKFRKGVI SVNDVMFSSS IMYRIKKNAF SLTVMAIISA 
301:	ITVSVLCFAA ISRASLSSEI KYTAPHDVTI KDQQKANQLA SELNNQKIPH FYNYKEVIHT 
361:	KLYKDNLFDV KAKEPYNVTI TSDKYIPNTD LKRGQADLFV AEGSIKDLVK HKKHGKAIIG 
421:	TKKHHVNIKL RKDINKIYFM TDVDLGGPTF VLNDKDYQEI RKYTKAKHIV SQFGFDLKHK 
481:	KDALALEKAK NKVDKSIETR SEAISSISSL TGILLFVTSF LGITFLIAVC CIIYIKQIDE 
541:	TEDELENYSI LRKLGFTQKD MARGLKFKIM FNFGLPLVIA LSHAYFTSLA YMKLMGTTNQ 
601:	IPVFIVMGLY ICMYAVFAVT AYNHSKRTIR HSI