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1.C.3.4.5
Beta-channel-forming cytolysin, the  synergohymenotropic toxin, of 310 aas.  Bacterial infections from Staphylococcus pseudintermedius are the most common cause of skin infections (pyoderma) affecting dogs. Two component pore-forming leukocidins are a family of potent toxins secreted by staphylococci and consist of S (slow) and F (fast) components. They impair the innate immune system, the first line of defense against these pathogens. Seven different leukocidins have been characterized in Staphylococcus aureus, some of which are host and cell specific. Abouelkhair et al. 2018 identified two proteins, named "LukS-I" and "LukF-I", encoded on a degenerate prophage contained in the genome of S. pseudintermedius isolates. The killing effect of recombinant S. pseudintermedius LukS-I together with LukF-I on canine polymorphonuclear leukocytes depended on both constituents of the two-component pore-forming leukocidin.

Accession Number:ADX76265.1
Protein Name:ADX76265.1 synergohymenotropic toxin [Staphylococcus pseudintermedius ED99]
Length:327
Molecular Weight:
Species:Staphylococcus pseudintermedius ED99 [984892]
Number of TMSs:1
Substrate

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FASTA formatted sequence
1:	MKISKVIKAA TATSVALMLF SNPVYAANQI TPVSEKKVDD KITLYKTTAT ADSDKLNISQ 
61:	LLTFNFIKDK SYDKDTLVLK AAGNINSGYK SPNPNDYIYS SFYWGAKYNV SISAESKGAV 
121:	NVVDYAPKNQ NEEFQVQNTL GYSFGGDISI SKGLSGGLNG SESFSETINY KQESYRTTID 
181:	KHTDNKTIGW GVEAHKIMNA GWGPYGRDSF HDLYGNELFL GGRQSKLNAG QNFLPTSQMP 
241:	LLARGNFNPE FLSVLSHKPN GAKTSKIKVT YQREMDEYTN YWNGFHWMGT NYKNQNNATF 
301:	TSFYEIDWDQ HTVKLIKTHS DEKNPS