1.C.3.4.5 Beta-channel-forming cytolysin, the synergohymenotropic toxin, of 310 aas. Bacterial infections from Staphylococcus pseudintermedius are the most
common cause of skin infections (pyoderma) affecting dogs. Two component
pore-forming leukocidins are a family of potent toxins secreted by staphylococci and consist of S (slow) and F (fast)
components. They impair the innate immune system, the first line of
defense against these pathogens. Seven different leukocidins have been
characterized in Staphylococcus aureus, some of which are host and cell
specific. Abouelkhair et al. 2018 identified two proteins, named "LukS-I" and "LukF-I", encoded on a
degenerate prophage contained in the genome of S. pseudintermedius isolates. The killing effect of recombinant S.
pseudintermedius LukS-I together with LukF-I on canine polymorphonuclear
leukocytes depended on both constituents of the two-component pore-forming leukocidin.
|
Accession Number: | ADX76265.1 |
Protein Name: | ADX76265.1 synergohymenotropic toxin [Staphylococcus pseudintermedius ED99] |
Length: | 327 |
Molecular Weight: | |
Species: | Staphylococcus pseudintermedius ED99 [984892] |
Number of TMSs: | 1 |
Substrate |
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1: MKISKVIKAA TATSVALMLF SNPVYAANQI TPVSEKKVDD KITLYKTTAT ADSDKLNISQ
61: LLTFNFIKDK SYDKDTLVLK AAGNINSGYK SPNPNDYIYS SFYWGAKYNV SISAESKGAV
121: NVVDYAPKNQ NEEFQVQNTL GYSFGGDISI SKGLSGGLNG SESFSETINY KQESYRTTID
181: KHTDNKTIGW GVEAHKIMNA GWGPYGRDSF HDLYGNELFL GGRQSKLNAG QNFLPTSQMP
241: LLARGNFNPE FLSVLSHKPN GAKTSKIKVT YQREMDEYTN YWNGFHWMGT NYKNQNNATF
301: TSFYEIDWDQ HTVKLIKTHS DEKNPS