2.A.6.2.14
SmeVWX MDR efflux pump. Drugs include chloramphenicol, quinolones, tetracyclines and aminoglycosides, but not β-lactams and erythromycin (Chen et al., 2011).
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| Accession Number: | B2FLY4 |
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| Protein Name: | Putative drug resistance membrane fusion protein |
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| Length: | 1056 |
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| Molecular Weight: | 113539.00 |
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| Species: | Stenotrophomonas maltophilia (strain K279a) [522373] |
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| Number of TMSs: | 12 |
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| Substrate |
chloramphenicol, tetracycline, amino cyclitol glycoside, diterpene |
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1: MDFSRFFIDR PIFAAVLSIV IFAAGLITIP ILPISEYPEV VPPSVVVRTV YPGANPKVIA
61: ETVATPLEEA INGVEGMMYL KSVAGSDGVL QMTVTFRPGT DPDAAAVKVQ NRVAQAQARL
121: PEDVRRQGVT TQKQSPTFLM VVHLTSPQGK YDTLYLRNYA RLHVKDALAR IPGVGDAQIF
181: GGGDYAMRAW LDPDKVASRG LTASDVVRAM REQNVQVSAG QLGAEPLPDS KFLTLINAQG
241: RLKTEKEFGD IVLKSGTDGE IVRLSDVARL ELGAGDYTLR SQLDGKNAVG IGIFQSPGAN
301: ALEIRDQVIS TMDEMQKTMP ADVKYEAVYD TTIFVRDSIK AVVSTLLEAI ALVVLVVILF
361: LQTWRASIIP LIAVPVSVVG TFAALYLLGF SINTLSLFGL VLAIGIVVDD AIVVVENVER
421: NIEEGLSPTA AAHQAMREVS GPIVAIALVL CAVFVPMAFL SGVTGQFYKQ FAVTIAISTV
481: ISAINSLTLS PALAARLLKA HGAPKDGPSR LIDRLFGWVF RPFNRFFKSS SEKYERGVAR
541: ILGRRGAVFV VYAILLVGTG VIFKLVPPGF IPTQDKLYLI AGVKLPEGSS IARTDEMLRK
601: VAKIAQETDG VAHTISFPGL NALQFTNTPN TGVAFIPLKP FAERHGRTAA QINAEINQKI
661: AGLQEGFAFA MMPPPILGLG NGNGYQMFIE DRGNLGYGAL QNAVQAMQGT VAQTPGMAFP
721: ISSYQANVPQ LDAEVDRVKA KAQGVQLTEL FDTLQTYLGS AYVNDFNQFG RTWQVIAQAD
781: GPFRETVEDI GKLRTRNDRG EMVPIGSMVT IKQTFGPDPV LRFNGYPAAD LAGEADPRLL
841: SSAEAMTKLT EIAGKVLPVG MTTEWTDLSY QQATQGKAAF IVFPVAIMLA FLVLAALYES
901: WSLPLAVILI VPMTLLSALF GVWLTGGDNN VFVQVGLVVL MGLACKNAIL IVEFARELEM
961: GGKGIVEAAL EACRLRLRPI VMTSIAFIAG TVPLVLSHGA GAEVRSVTGI TVFAGMLGVT
1021: LFGLFLTPVF YVALRKFVTR NGGGQLVQHG EPTIHH