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3.A.3.7.3
Potassium transporter, KdpABC, with 3 subunits:  KdpA, B2HPR5, 552 aas and 10 TMSs in a 2 + 2 + 2 + 2 + 2 arrangement; KdpB ATPase, B2HRP6, 693 aas and 7  TMSs in a 2 + 2 + 3 TMS arrangement, and KdpC, D2HRP7, 296 aas with one N-terminal TMS and possibly one C-terminal TMS.  A kdpA null mutantion reduced the fraction of persisters after exposure to rifampicin (Liu et al. 2020). kdpA encodes a transmembrane protein that is part of the Kdp-ATPase, an ATP-dependent high-affinity potassium (K+) transport system. kdpA expression is induced under low K+ conditions and is required for pH homeostasis and growth in media with low concentrations of K+. Inactivation of the Kdp system caused hyperpolarization of the membrane potential, increased the proton motive force (PMF) and elevated levels of intracellular ATP. The KdpA mutant phenotype could be complemented with a functional kdpA gene or supplementation with high K+ concentrations. Thus, the Kdp system is required for ATP homeostasis and persister formation. ATP-mediated regulation of persister formation may be a general mechanism in bacteria, and suggest that K+ transporters may play a role in the regulation of ATP levels and persistence (Liu et al. 2020).

Accession Number:B2HPR5
Protein Name:Potassium-transporting ATPase potassium-binding subunit
Length:552
Molecular Weight:58169.00
Species:Mycobacterium marinum (strain ATCC BAA-535 / M) [216594]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate

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FASTA formatted sequence
1:	MAGILFLASL MVALVAVHVP FGDYMYRVYT SDKHSRVERW IYRAIGADPH AEQGWGAYAR 
61:	SVLAFSASGI LVLFTFQLMQ GKLPLHLNDP ATPMNPVLAW NTAVSFVTNT NWQAYSGEST 
121:	QGHLVQMAGL AVQNFVSAAV GMAVAMAVVR GFARRHTGDL GNFWVDLVRG TIRILLPVSV 
181:	VAAIVLVAGG AIQNFHLRDQ IVSTLSGAEQ TITGGPVASQ ETIKDLGTNG GGFFNVNSAH 
241:	PFENPTAWTN WVEIFLLLVI SFSLPRTFGR MVGSPKQGIA IASVMAVLAL ISWSTTMSMQ 
301:	LQRHGTVPTA VGAAMEGVEQ RFGVANSAVF AASTTLTSTG SVDSFHDSYT SLGGLVLLLN 
361:	MQLGEVAPGG VGSGLFGMLI LAVITVFIAG LMVGRTPEYL GKKITPREIK LAATYLLISP 
421:	LIALTGSAVA MAMPGQRAAM LNTGPHGLSE VLYAFTSAAN NNGSAFAGIS VNTDWYNTAL 
481:	GLAMVFGRFL PIVLVLALAG SLVRQGTTPE SIGTLPTHRP QFVGLVAGVT LILVALTFLP 
541:	MLALGPLAEG IH