2.A.108.2.10
Dipartite iron uptake system, FetM (646 aas; 8 TMSs in a 1 + 7 TMS arrangement)/FetP (a periplasmic protein that enhances iron uptake by FetM) (Koch et al. 2011). FetP binds Cu2+ and Mn2+ at two different sites, 1.3 Å apart, in this homodimeric protein, and the 3-d structure with Cu2+ bound to each of the two subunits reveals different geometries at the two sites. FetMP may be an iron permease with an iron scavenging function, and possibly also an iron reducing function (Koch et al. 2011).
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| Accession Number: | B3HWD6 |
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| Protein Name: | High-affinity Fe2+/Pb2+ permease |
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| Length: | 646 |
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| Molecular Weight: | 72237.00 |
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| Species: | Escherichia coli F11 [340197] |
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| Number of TMSs: | 8 |
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| Substrate |
iron atom |
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1: MRNFRNSLLV TLFGLFISMS VWASTNYAPL IEDIEQRLDK TAELYQQQHA DEARRTVQMA
61: YFEVFENLEG PIRINISARK SYEMESAFGE IRRMIGEKKP LADVQARIDW LKAALREVEP
121: VLDGGHRLVA EEQHNALSRD DIAVHWQESF RTIDDLLAQA VTEYQAGNYS VASQHVQQAH
181: YQGFKNSEME MSLRQNRSAK DAASINQQFS SLIALTAQPD HLNDVSYQVT TLLQDIEDIL
241: PGLPTTRDDQ QVAAAQSADN IPAADEGNNR TDWAEVTTGI NQSIQDAIAR YQGGDAKNAI
301: LDIQDTYFDR FEASGMENKI GSRDSAFKTT LEAYFTRLVS LMKAGQPVER LNAEASALAQ
361: DLQKAVTMLG EGEETQWSLL LYSLMIIVRE GLEALLIVAA IVAYMVKNNH QDKLPLIRQS
421: VIVALIASVI TAAIFQMLFT NSGASRELLE GITMLIAVVM LFFMSYWLLS KVEARHWKAW
481: LEGKLSHSLS RGSLVGLWLT SFLAVYREGA ETVLFYYALI GDANTVSGHM AIGAGFVIGC
541: VVLLLAWLVM RYSVVRLPLK PFFMFTGSFM YLMAFVFAGK GVLELVEGKL FQPTLINGFP
601: EISWLGIYPY VETLLPQVVL LLAALVALWV MRRKSAVPGE TIKNNP