1.C.3.4.5 Beta-channel-forming cytolysin, the synergohymenotropic toxin, of 310 aas. Bacterial infections from Staphylococcus pseudintermedius are the most
common cause of skin infections (pyoderma) affecting dogs. Two component
pore-forming leukocidins are a family of potent toxins secreted by staphylococci and consist of S (slow) and F (fast)
components. They impair the innate immune system, the first line of
defense against these pathogens. Seven different leukocidins have been
characterized in Staphylococcus aureus, some of which are host and cell
specific. Abouelkhair et al. 2018 identified two proteins, named "LukS-I" and "LukF-I", encoded on a
degenerate prophage contained in the genome of S. pseudintermedius isolates. The killing effect of recombinant S.
pseudintermedius LukS-I together with LukF-I on canine polymorphonuclear
leukocytes depended on both constituents of the two-component pore-forming leukocidin.
|
Accession Number: | B5D5T8 |
Protein Name: | Beta-channel forming cytolysin |
Length: | 310 |
Molecular Weight: | 35136.00 |
Species: | Staphylococcus pseudintermedius [283734] |
Number of TMSs: | 1 |
Substrate |
|
---|
1: MVKNKLLAAT LSISLVLPLI TPYSEEAKAA NTIEEIGEGA QIIKRTEDVS SRKWGVTQNI
61: QFDFVKDPKY NKDALIIKMQ GFIKSRTSFT DVKGKGYEST KRMLWPFQYN IALKTNDPNV
121: SLINYLPKNK IESIDVSQTL GYNVGGNFQS APLLGGKGAF NYSKKISYTQ KNYISEVAQQ
181: NSKNIRWEVK ANSFNTENGQ VSAYDRHLFV RSPIGPNARD FFVPNDELPP LIQSGFNPSF
241: IATVSHEKDK GDTSEFEIAY GRNLDITYAT FFPRTGIFAE RRHNALMNRN LVTKYEVNWK
301: THEIKVKGHN