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1.C.3.4.5
Beta-channel-forming cytolysin, the  synergohymenotropic toxin, of 310 aas.  Bacterial infections from Staphylococcus pseudintermedius are the most common cause of skin infections (pyoderma) affecting dogs. Two component pore-forming leukocidins are a family of potent toxins secreted by staphylococci and consist of S (slow) and F (fast) components. They impair the innate immune system, the first line of defense against these pathogens. Seven different leukocidins have been characterized in Staphylococcus aureus, some of which are host and cell specific. Abouelkhair et al. 2018 identified two proteins, named "LukS-I" and "LukF-I", encoded on a degenerate prophage contained in the genome of S. pseudintermedius isolates. The killing effect of recombinant S. pseudintermedius LukS-I together with LukF-I on canine polymorphonuclear leukocytes depended on both constituents of the two-component pore-forming leukocidin.

Accession Number:B5D5T8
Protein Name:Beta-channel forming cytolysin
Length:310
Molecular Weight:35136.00
Species:Staphylococcus pseudintermedius [283734]
Number of TMSs:1
Substrate

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FASTA formatted sequence
1:	MVKNKLLAAT LSISLVLPLI TPYSEEAKAA NTIEEIGEGA QIIKRTEDVS SRKWGVTQNI 
61:	QFDFVKDPKY NKDALIIKMQ GFIKSRTSFT DVKGKGYEST KRMLWPFQYN IALKTNDPNV 
121:	SLINYLPKNK IESIDVSQTL GYNVGGNFQS APLLGGKGAF NYSKKISYTQ KNYISEVAQQ 
181:	NSKNIRWEVK ANSFNTENGQ VSAYDRHLFV RSPIGPNARD FFVPNDELPP LIQSGFNPSF 
241:	IATVSHEKDK GDTSEFEIAY GRNLDITYAT FFPRTGIFAE RRHNALMNRN LVTKYEVNWK 
301:	THEIKVKGHN