9.A.8.1.10
FeoABC Fe2+ transporter (Hung et al., 2012). FeoA is a 75 aa protein homologous to the N-terminus of FeoB2 of Porphyromonas gingivalis (TC#9.A.8.1.6) and with some sequence similarity to an internal hydrophilic segment of the RND heavy metal porter, CzcA of Myxococcus xanthus (TC#2.A.6.1.7). Linkous et al. 2019 have determined the crystal structure of FeoA from Klebsiella pneumoniae (KpFeoA). The structure reveals an SH3-like domain
that mediates interactions between neighboring polypeptides via
hydrophobic intercalations into a Leu-rich surface ridge. Using docking
of a small peptide corresponding to a postulated FeoB partner binding
site, they demonstrated that KpFeoA can assume both "open" and "closed"
conformations, controlled by binding at this Leu-rich ridge. They propose a
model in which a "C-shaped" clamp along the FeoA surface mediates
interactions with its partner protein, FeoB (Linkous et al. 2019).
|
| Accession Number: | B5XTS7 |
|---|
| Protein Name: | Ferrous iron transport protein B |
|---|
| Length: | 772 |
|---|
| Molecular Weight: | 83897.00 |
|---|
| Species: | Klebsiella pneumoniae (strain 342) [507522] |
|---|
| Number of TMSs: | 11 |
|---|
| Substrate |
iron(2+) |
|---|
1: MKKLTVGLIG NPNSGKTTLF NQLTGARQRV GNWAGVTVER KEGVFATTDH QVTLVDLPGT
61: YSLTTISSQT SLDEQIACHY ILSGDADMLI NVVDASNLER NLYLTLQLLE LGIPCVVALN
121: MLDIAEKQQV RIDIDALAAR LGCPVIPLVS TRGRGIEALK IALDRHQANS DIELVHYPQP
181: LLREADLLAQ QMSAQIPTRQ RRWLGLQMLE GDIYSRAYAG DAADKLDIAL ANLSDEIDDP
241: ALHIADARYQ TIAAVCDAVS NTLTAEPSRF TAAMDKVILN RFLGLPIFLF VMYLMFLLAI
301: NIGGALQPIF DAGSVAVFIH GIQWLGYTLH FPDWLTVFLA QGIGGGINTV LPLVPQIGMM
361: YLFLSFLEDS GYMARAAFVM DRLMQALGLP GKSFVPLIVG FGCNVPSVMG ARTLDAPRER
421: LMTIMMAPFM SCGARLAIFA VFAAAFFGQN GALAVFSLYV LGIVMAILTG LMLKHTIMRG
481: EASPFVMELP VYHVPHIKSL IIQTWQRLKG FVLRAGKVIV IVSIFLSALN SFSLSGKVVD
541: NINDSALASV SRVITPVFKP IGVHEDNWQA TVGLFTGAMA KEVVVGTLNT LYTAEDIQNE
601: EFNPQTFSLG EELLAAVDET WQGLKDTFSL SVLANPIEAS KGDGEMATGA MGVMGSKFGS
661: AAAAYSYLIF VLLYIPCISV MGAIARESSR GWMTFSILWG LNIAYSLSTL YYQTVSFSDH
721: PRYSLVCILA VVLFNVVLFG LLRRARSRVD VSLLATRKTP ASCCSSPAGD CH