3.A.1.12.19
Ergothioheine uptake transporter (ABC-type), EgtUV, of 553 and 213 aas, respectively. While the first has 7 N-terminal TMSs and a binding protein domain C-terminally, EgtV is the ATPase subunit. The system transports human dietary antioxidants and 2-thioimidazole-containing low molecular weight thiol ergothioneine (Legg et al. 2025). OseR, a bacterial redox sensor, regulates
ergothioneine uptake via a Cys thiol switch, enhancing oxidative stress
resistance and virulence (Zhu et al. 2025).
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| Accession Number: | B5Z7I3 |
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| Protein Name: | Ergothioneine transport permease/ergothioneine binding protein EgtU |
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| Length: | 553 |
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| Molecular Weight: | 62678.00 |
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| Species: | Helicobacter pylori (strain G27) [563041] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ergothioneine |
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1: MLGMGVFKQL IKELYEWLLH SMDMATQHLV AIVLKISVVK YLIKEFHDRF IYFIDLLAQH
61: FIIVALSGFL VLVFGVLIGV FAFYNSKARA FLLPVVNFLY TIPSLALFAL FIPVIGVGLK
121: NALLVLVLYG LLPIVYSTYN ALKEVREEVI KAAIGLGCNP KELFFRVHFL LAIPQILAGL
181: RIAVVMLVAM AGIGALIGAG GLGQAIFRGL NTQNTTLLVA GSLIIALFSV LADKFVSVFQ
241: HENALQRLFS QNATQKQKRR VYTNLAVFLF LLLASALWLI PRNAIEEKPL VVATKPSSEQ
301: YILGEILSLL LEKHHIPIKR AFGIGGGTMN IHPALIRGDF DLYMEYTGTA WVNTLKNPLT
361: QKVDFETIKK RYEKEFNLLW VGLLGFNNTY SLAISKEDAQ KYAIETFSDL ALHSQNFDFG
421: AEFDFFERED AFKGLMKAYR FHFRSLHEMD INLRYKSFES HKINALDVFT TDAQIKELDL
481: KVLKDDKGFF PNYQAGIVIR KEIIKKYPEA LKILEKLDSK INDETMQDLN YQVEVLKKSP
541: KIVAKDFLER LGL