3.A.1.12.19
Ergothioheine uptake transporter (ABC-type), EgtUV, of 553 and 213 aas, respectively. While the first has 7 N-terminal TMSs and a binding protein domain C-terminally, EgtV is the ATPase subunit. The system transports human dietary antioxidants and 2-thioimidazole-containing low molecular weight thiol ergothioneine (Legg et al. 2025). OseR, a bacterial redox sensor, regulates
ergothioneine uptake via a Cys thiol switch, enhancing oxidative stress
resistance and virulence (Zhu et al. 2025).
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| Accession Number: | B5Z7I4 |
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| Protein Name: | Ergothioneine transport ATP-binding protein EgtV |
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| Length: | 213 |
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| Molecular Weight: | 23640.00 |
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| Species: | Helicobacter pylori (strain G27) [563041] |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Peripheral membrane protein2 |
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| Substrate |
ergothioneine |
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1: MKEIVTIENV SFNYRNRAVF KDFNLSIEKG DFLCVLGESG SGKSTLLGLI LGLLKPSLGS
61: VKIFNETLSN NAFLRQKIGY IAQGNSLFSH LNALQNMTFC LNLQGINKQA AQKEAKALAL
121: KMGLDESLMD KFPNELSGGQ AQRVGIIRGI IHKPELILLD EPFSALDSFN RKNLQDLIKE
181: IHQNSCATFI MVTHDEEEAQ KLATKTLEIK ALK