2.A.6.1.16
The nczCBA operon (also called the czc operon) is induced maximally by Ni2+ and Co2+, moderately by Zn2+ but not by Cd2+. NczCBA transports Ni2+ Co2+and probably Zn2+ and Cd2+(Valencia et al. 2013).
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| Accession Number: | B8GZE9 |
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| Protein Name: | Cobalt-zinc-cadmium resistance protein czcA |
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| Length: | 1057 |
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| Molecular Weight: | 113054.00 |
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| Species: | Caulobacter crescentus (strain NA1000 / CB15N) [565050] |
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| Number of TMSs: | 12 |
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| Substrate |
cadmium(2+), cobalt(2+), nickel(2+), zinc(2+) |
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1: MKSPAPATTI REATMLERII AASIRLRWVV LALVALSAAV GIWSFQRLPI DATPDITNIQ
61: VQINTEAPGF SPLEAEQRVT FPVETAIAGL PGLQYTRSVS RYGLSQVTVV FKDGTDIYFA
121: RQLVGERLQS ARAQLPPGVN PEMGPISTGL GEIFMYTVEA KPGARRPDGK AWTPEDLRTL
181: QDWVIRPQLR NTPGVTEVNT IGGFERQYHV TPLPDRLSAY GLTMGDVVTA LEKNNANVGA
241: GYIERYGEQY LIRVPGQATG VEDLKAVIVA SRNGAPIRVA DIADVGLGEE LRTGAATENG
301: QEVVLGTVFM LVGENSRTVA RATAARLEEA AKALPAGVTA EPIYDRTNLV DRAIATVEKN
361: LVEGAILVIV VLFLLLGNIR AALITAAVIP LSMFLTITGM VQSKVSGNLM SLGALDFGLI
421: VDGAVIIVEN CLRRLGEAQH RYGRLLSRDE RFALVAGATS EVIRPSLFGV LIITLVYVPI
481: FALTGVEGKM FHPMAITVVI ALTAALVLSL TFVPAAVALF VTGKVEEKEN LIMRGARRLY
541: EPALETALRL RVAFVAGAVL LVAIAAFAAS RMGSEFVPNL DEGDIAMHAL RIPGTSLSQA
601: IAMQTALEAK VKTLPEVDRV VSKIGTAEVA TDPMPPSVAD TFIMLKDRKD WPDPRKPRAQ
661: LVAELEAVVA KVPGNNYEFT QPIQMRFNEL LSGVRADVAV KVFGDDLDQL LAIGEQIGGV
721: IEGVEGAQDV GVEQVTGLPV LQITPDRAAL ARLGLNVDDV QSVVATAIGG TVTGQVFEGD
781: RRFDVVVRLP EAVRGRIDDI GRLRIPLPGA IDQPRGFVPL QDVARIEMVI GPNQISREDG
841: KRRIVVTANV RGRDLGSFIT EVQRKVGAQV ELPTGYWITY GGAFEQLISA AQRLQLVVPA
901: ALLLIFGLLY ALFRSVKDAA IVFSGVPLAL TGGVAALLLR GMPLSISAGV GFIALSGVAV
961: LNGVVMVSFI RTLRQQGTDV DHAIREGALT RLRPVLMTAL VASLGFVPMA FNVGAGAEVQ
1021: RPLATVVIGG IISSTLLTLQ VLPALYRLAY SQARAVR