3.A.1.135.4
Multidrug resistance ABC exporter, PatAB (PatA, 564 aas; PatB, 588 aas) (Bidossi et al. 2012). Drug-dependent inhibition of nucleotide hydrolysis by PatAB has been demonstrated (Guffick et al. 2022). Ethidium-like inhibition was observed with propidium, novobiocin and coumermycin A1, which all inhibit nucleotide hydrolysis by a non-competitive mechanism. This fact casts light on potential mechanisms by which drugs can regulate nucleotide hydrolysis by PatAB, which might involve a novel drug binding site near the nucleotide-binding domains (Guffick et al. 2022).
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| Accession Number: | B8ZPD1 |
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| Protein Name: | ABC transporter ATP-binding membrane protein |
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| Length: | 588 |
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| Molecular Weight: | 65702.00 |
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| Species: | Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1) [561276] |
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| Number of TMSs: | 5 |
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| Substrate |
drug |
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1: MKTVQFFWHY FKVYKFSFVV VILMIVLATF AQALFPVFSG QAVTQLANLV QAYQNGNPEL
61: VWQSLSGIMV NLGLLVLVLF ISSVIYMCLM TRVIAESTNE MRKGLFGKLA QLTVSFFDRR
121: QDGDILSHFT SDLDNILQAF NESLIQVMSN IVLYIGLILV MFSRNVTLAL ITIASTPLAF
181: LMLIFIVKMA RKYTNLQQKE VGKLNAYMDE SISGQKAVIV QGIQEDMMAG FLEQNERVRK
241: ATFKGRMFSG ILFPVMNGMS LINTAIVIFA GSAVLLNDKS IETSTALGLI VMFAQFSQQY
301: YQPIIQVAAS WGSLQLAFTG AERIQEMFDA EEEIRPEKAP TFTKLQESVE ISHIDFSYLP
361: DKPILKDVSI SAPKGQMTAV VGPTGSGKTT IMNLINRFYD VDAGGIYFDG KDIRGYDLDS
421: LRSKVGIVLQ DSVLFSGTIR DNIRFGVPDA NQEMVEVAAK ATHIHDYIES LPDKYDTLID
481: DDQSIFSTGQ KQLISIARTL MTDPEVLILD EATSNVDTVT ESKIQHAMEV VVAGRTSFVI
541: AHRLKTILNA DQIIVLKDGE VIERGNHHEL LKLGGFYSEL YHNQFVFE