3.A.1.135.4
Multidrug resistance ABC exporter, PatAB (PatA, 564 aas; PatB, 588 aas) (Bidossi et al. 2012). Drug-dependent inhibition of nucleotide hydrolysis by PatAB has been demonstrated (Guffick et al. 2022). Ethidium-like inhibition was observed with propidium, novobiocin and coumermycin A1, which all inhibit nucleotide hydrolysis by a non-competitive mechanism. This fact casts light on potential mechanisms by which drugs can regulate nucleotide hydrolysis by PatAB, which might involve a novel drug binding site near the nucleotide-binding domains (Guffick et al. 2022).
|
| Accession Number: | B8ZPJ9 |
|---|
| Protein Name: | ABC transporter ATP-binding membrane protein |
|---|
| Length: | 564 |
|---|
| Molecular Weight: | 62150.00 |
|---|
| Species: | Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1) [561276] |
|---|
| Number of TMSs: | 6 |
|---|
| Substrate |
drug |
|---|
1: MLIQKIKTYK WQALASLLMT GLMVASSLLQ PRYLQEVLGA LLAGKYEAIY SIGAWLIGVA
61: VVGLVAGGLN VVLAAYIAQG VSSDLREDAF RKIQTFSYAD IEQFNAGNLV VRMTNDINQI
121: QNVVMMTFQI LFRLPLLFIG SFILAVQTLP SLWWVIVLMV VLIFGLTAVM MGMMGPRFAK
181: FQTLLERINA IAKENLRGVR VVKSFVQEKE QFAKFTEVSD ELLGQNLYIG YAFSVVEPFM
241: MLVGYGAVFL SIWLVAGMVQ SDPSVVGSIA SFVNYLSQII FTIVMVGFLG NSVSRAMISM
301: RRIREILDAE PAMTFKDIPD EELVGSLSFE NVTFTYPMDK EPMLKDVSFT IEPGQMVGVV
361: GATGAGKSTL AQLIPRLFDP QEGAIKIGGK DIREVSEGTL RKTVSIVLQR AILFSGTIAD
421: NLRQGKGNAT LFEMERAANI AQASEFIHRM EKTFESPVEE RGTNFSGGQK QRMSIARGIV
481: SNPRILIFDD STSALDAKSE RLVQEALNKD LKGTTTIIIA QKISSVVHAD KILVLNQGRL
541: IGQGTHADLV ANNAVYREIY ETQK