2.A.5.1.15
Zinc transporter, Zrt1 of 468 aas and 7 TMSs. Receives Zn2+ from the secreted, extracellular zincophore protein, Pra1 for uptake of the metal. The binding site in Pra1 is in the C-terminal region of this 299 aa protein (Łoboda and Rowińska-Żyrek 2017). Pra1 is a cell surface protein with a single N-terminal TMS involved in the
host-parasite interaction during candidal infection. With MP65, it
represents a major component of the biofilm matrix. It sequesters zinc from
host tissues and mediates leukocyte adhesion and migration (Citiulo et al. 2012).
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| Accession Number: | B9WF52 |
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| Protein Name: | Zinc-regulated transporter, putative |
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| Length: | 468 |
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| Molecular Weight: | 51211.00 |
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| Species: | Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast) [573826] |
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| Number of TMSs: | 7 |
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| Substrate |
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1: MKFAYLFFIV LLTKVCTETV TVLSTRSYRL PTTESNPTDG TVYLTLTRQQ SSSTSLDSST
61: ITSPPSNSSV IVQTTAITDC HFHNSVQYCV DGYGNEGSIL PAPTNINNLP TSYTGCHSHD
121: GDTFCMNGDN EVQFVKLEEE DNEGSSSSSG KKCHFHAGVE HCVGDNNHDA VTCERVERDY
181: DIPLRIGLLF VILVTSGIGS FGPIVLKQFV HLSQENYIIV IIKQFGTGII ISTAFVHLMT
241: HAQLMWSNSC LNIKYEGTSA SITMAGIFIA FIIEYIALRV LNTRDTTNDD KKEIEESSSN
301: EQSLHGISVN DKISVMILEA GIIFHSILIG ITLVVTDDVY FITLFIVIVF HQFFEGLALS
361: SRIISITNAN LSTKLVMALM FALITPIGMA IGIGVLNKFN GNDPATLIAL GTLDSFSAGV
421: LLWTGLIEMW SHDWLHGHLR NSSLLKTTVA LVSLVLGMLL MSLLGNWA