9.A.8.1.18
FeoABC ferrous iron (Fe2+) uptake system. All three subunits are required for activity (Gómez-Garzón et al. 2022). Subunits FeoA and FeoC are the same size and show very similar hydrophathy plots. Many Feo transport systems lack a FeoC subunit (e.g., see 9.A.8.1.19), and mutations in FeoA can eliminate the need for FeoC (see family description; Gómez-Garzón et al. 2022).
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| Accession Number: | C3LP27 |
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| Protein Name: | Ferrous iron transport protein B |
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| Length: | 758 |
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| Molecular Weight: | 83115.00 |
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| Species: | Vibrio cholerae serotype O1 (strain M66-2) [579112] |
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| Number of TMSs: | 9 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 |
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| Substrate |
iron(2+) |
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1: MKYQVLTVGN PNSGKTTLFN GLTGAKQQVG NWAGVTVEKK TGSFVHAGDE FSLTDLPGIY
61: ALDSGNDSNS IDESIASRAV LTHPADVIIN VVDATCLERS LYMTLQLREL RRPMIVVLNK
121: MDALKRERVH LDLKQLEAFL GCPVLALSAN NKEQVRRFKE KLHKLLVQGI ALKQIELHYG
181: AEFESLIHEL EPMFAEQAVS ARALAIRALE NDRLVINGLK EAERQNVEQR QHECQVDIDL
241: LVANVRYTYL HELCTHVRRT EGKLSHKFTE KADRVILNKW VGIPFFFAVM YLMFMFSINI
301: GSAFIDFFDI GVGALLVDGG HHLLDDHLPV WLVTLIADGV GGGIQTVATF IPVIACLYLF
361: LAVLESSGYM SRAAFVLDKV MQKIGLPGKA FVPLVLGFGC NVPSIMATRT LDQERERKLA
421: ASMAPFMSCG ARLPVYALFA AAFFPQSGQN VVFALYLLGI VAAVLTGLVL KKTLYPGVSE
481: SLIMDMPDYE IPTLQNVVIK TWQKLKRFVL GAGKTIVVVV TILSFLNSVG TDGSFGNENS
541: DKSVLSKAAQ FVTPVFSPMG VTQENWPATV GIITGIFAKE AVVGTLNSLY TSTPDAEEAA
601: EYDLLASLQE ALMTIPDNLA GLSFSDPLGI EVGDLTDTEA VAQEQEVDGS IFGNLHTYFA
661: NAHVAFAYLI FILLYTPCVA AMGAYVREFG AAYARFIAVW TMGLAYGSAV LYYQATHIAE
721: HPMYSLIWIG VIVGIGFATY WALKQTGRKQ KMIEVSVA