1.A.83.1.6
Minor capsid protein VP2/VP3 complex.  Isoforms VP2 and VP3 are structural proteins that reside within the core of the capsid surrounded by 72 VP1 pentamers. They participate in host cell receptor binding together with VP1, the major capsid protein. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the ER membrane to the cytoplasm. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of a VP2 or Vp3 nuclear localization signal (shared C-terminus). hey play a role in virion assembly within the nucleus, in particular through a DNA-binding domain located in the C-terminal region. N-terminal myristoylation suggests a scaffold function for virion assembly.