1.A.17.4.13
Tmc1/Tmc2a or Tmc2b/protocadherin 15a (Pcdh15a). The complex is part of a mechanotransduction system (Maeda et al. 2014). Its trafficing to the plasma membrane depends on the transmembrane O-methyltransferase (TOMT/LRTOMT; 259 aas, 1 N-terminal TMS) (Erickson et al. 2017). Water motion is dependent on this complex (Chou et al. 2017). The role of another protein, Tmie (see TC# 8.A.115), in sensory hair cells is to target and stabilize the Tmc channel subunits to the stereocilia, the site of mechano-electrical transduction (Pacentine and Nicolson 2019). Tmc proteins 1, 2a and 2b are essential for zebrafish hearing although Tmc1 is not, probably because they can (at least partially) substitute for each other (Chen et al. 2020). There are two distinct cell types in inner ear hairs, an upper layer of teardrop shaped cells that rely on Tmc2a, and a lower layer of gourd shaped cells that rely on Tmc1/2b (Smith et al. 2020). Tmc reliance in the ear is dependent on the organ, subtype of hair cell, position within the ear, and axis of best sensitivity (Zhu et al. 2020).
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| Accession Number: | E7FFT2 |
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| Protein Name: | Transmembrane channel-like protein |
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| Length: | 916 |
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| Molecular Weight: | 103312.00 |
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| Species: | Danio rerio (Zebrafish) [7955] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MPKKSDTTRK LEDVGIEIDG DVDSAEEDKK SKGKGGKKAA GGKRGKASED GEDEDEDDKP
61: PKGRRAANKK KPAPVDEEDS DDDIPQRRSA GNRRRGNVRE RGDGDKKKSG KKGRRGGKKN
121: EKGKGKDSDK DSDKDEKKKK NSSGDESDSD EEDESMSEGE MAKLMEEVEE KKKLIANIRN
181: KPWRMRRRLK VLKEAQQFVD KFEGALGKGK GRKLYAYKVM MMKKWIKFKR DFENFRTACI
241: PWERKIKEVE SHFGSSVASY FIFLRWMYGM NLVLFSLTFG LVVIPEVLMG LPYGSIPRKT
301: VPREDQDTAM DYSVLTDFNG YCKYSVLFYG YYNNQRTIGF LKFRLPLSYL MVGIGTFGYS
361: LMVVIRTMAK NADVGGGDGE DNEFTFAWKM FTSWDYLIGN AETADNKYAS ITTSFKESIV
421: DEQENQKDEN IHLRRFLRVL ANFLITCTLG GSGYLIYFVV KRSQEFQNMD NLSWYEKNEL
481: EIIMSLLGLV GPMLFETIAE LEEYHPRIAL KWQLGRIFAL FLGNLYTFLL ALFDEVNAKL
541: EEEESIKNAS IWFLKEYYAN YTANNPNDTG TPPPINPADA IRGPCWETTV GVEFVKLTIS
601: DIQVTYLTIL IGDFLRAFIV RFLNYCWCWD LEAGWPSYGE FDISGNVLGL VFNQGMIWMG
661: AFYAPGLVGI NVLRLLSSMY YQCWAVMACN VPHERVFKAS KSNNFYMGLL LLILFLSLLP
721: VVYTIMSLPP SFDCGPFSGK ERMFDVVMET IDLDLPAFMG TLFGYVANPG LVISAVLLMV
781: LAIYYLNSVS EAYKNSNNEL KKKMQMARDE EKNRRNNKDS TNQVMKDLED LLPNRPPTPP
841: SPRENIAEKN QGQGGKSAKV KPGTAGGVHL QKDVSLASAN PNARGPVTRA PGPRGPGPLP
901: GQPGAGRGQG PPPRRQ